酸、碱催化Knoevenagel缩合反应机理的研究  

The Acid/Basic Catalytic Mechanism of Knoevenagel Condensation Reaction

作　　者：高文秀[1] 吕杰琼 谢晖 孔长剑 王雪平 姚凯宁 郭胜男 Gao Wenxiu;Lyu Jieqiong;Xie Hui;Kong Changjian;Wang Xueping;Yao Kaining;Guo Shengnan(School of Chemical and Pharmaceutical Engineering,Jilin Institute of Chemical Technology,Jilin 132022,China)

机构地区：[1]吉林化工学院化学与制药工程学院,吉林吉林132022

出　　处：《山东化工》2021年第1期105-107,共3页Shandong Chemical Industry

基　　金：吉林省教育厅科研规划项目(JJKH20200240KJ),吉林市科技局杰出青年人才培养项目(201831757)。

摘　　要：Knoevenagel缩合反应在有机合成化学中是形成C-C双键的重要反应之一,所制备的化合物在医药、精细化工、生物科学等诸多领域有着广泛的应用。文章综述了近年来酸、碱催化Knoevenagel缩合反应的机理,为新型催化剂的开发和研究提供理论依据。Knoevenagel condensation reaction is one of the important reactions to form C-C double bonds in organic synthetic chemistry.The prepared compounds have a wide application in many fields such as medicine,fine chemicals,biological sciences,and so forth.In this paper,the acid/basic catalytic mechanism of the Knoevenagel condensation reaction is reviewed,which provides the theoretical reasons for the further study of new Knoevenagel condensation reaction catalysts.

关 键 词：KNOEVENAGEL缩合反应 酸性催化剂 碱性催化剂 反应机理 

分 类 号：O643.31[理学—物理化学]