BINOL硫脲催化合成羟甲基吡喃酮衍生物的性能  

Synthesis of hydroxymethylpyranone derivatives catalyzed by BINOL thiourea

作　　者：杨志翔 陈平平 李淼 陈治明[2,3] Yang Zhixiang;Chen Pingping;Li Miao;Chen Zhiming(Physical and Chemical Inspection Institute of Sichuan Center for Disease Control and Prevention, Chengdu 610041,Sichuan,China;School of Chemistry and Materials Science,Guizhou Normal University, Guiyang 550001,Guizhou,China;Key Laboratory for Functional Materials Chemistry of Guizhou Province,Guiyang 550001,Guizhou,China)

机构地区：[1]四川省疾病预防控制中心理化检验所,四川成都610041 [2]贵州师范大学化学与材料科学学院,贵州贵阳550001 [3]贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《工业催化》2020年第12期59-65,共7页Industrial Catalysis

基　　金：国家自然科学基金资助项目(21362006)。

摘　　要：探究合成羟甲基吡喃酮衍生物的方法,用BINOL硫脲(Ⅰ~Ⅳ)催化四氢吡喃酮与苯甲醛的不对称Aldol反应,简单、高效催化合成羟甲基吡喃酮衍生物,并考察催化剂的催化性能。结果表明,以Ⅱ(X=10%)为催化剂,CH2Cl2为溶剂,于10℃反应,合成的羟甲基吡喃酮衍生物有较好的收率(最高达82%)和较高的对映选择性(最高为86%ee)。The highly efficient method of synthesizing hydroxymethylpyranone derivatives was explored.In the asymmetric Aldol reaction of tetrahydropyranone and benzaldehyde catalyzed by BINOL thiourea(Ⅰ~Ⅳ),the hydroxymethylpyranone derivatives were synthesized ordinarily and efficiently,and the performance of the catalyst was also investigated.The results show that the hydroxymethylpyranone derivatives has good yield(up to 82%)and high enantioselectivity(up to 86%ee)when the catalyst isⅡ(X=10%)under the conditions of 10℃in the solvent CH2Cl2.

关 键 词：精细化学工程 BINOL硫脲 催化合成 羟甲基吡喃酮衍生物 不对称ALDOL反应 

分 类 号：O643.36[理学—物理化学] O626[理学—化学]