寄生虫谷胱甘肽转移酶的研究进展  

Advances in the research of glutathione S-transferase in parasites

作　　者：李爽 刘群 LI Shuang;LIU Qun(National Animal Protozoa Laboratory,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学,动物医学院,国家动物寄生原虫实验室,北京100193

出　　处：《中国兽医科学》2021年第1期113-118,共6页Chinese Veterinary Science

基　　金：国家自然科学基金项目(31730096);“十三五”国家重点研发计划项目(2017YFD0500404)。

摘　　要：谷胱甘肽转移酶(glutathione S-transfer,aGsSeT)是由多基因编码、具有多种功能的超基因家族酶,是细胞内转运的"通用"载体蛋白。哺乳动物的GST可调控细胞增殖和死亡信号通路,具有参与运输、新陈代谢和生理反应等的能力。已有研究表明,多种寄生虫的GST参与虫体的生命活动。综述了有关寄生虫GST的研究进展,为后续相关研究提供思路。Glutathione S-transferase(GST)is a supergene family enzyme encoded by a supergene family which has multiple functions.They were thought to be‘all-purpose’carrier proteins involved in intracellular transport.Mammalian GST regulates cell proliferation and death signaling pathways and is involved in transportation,metabolism,and physiological responses.Previous studies have demonstrated that GST of various parasites plays an important role in diversified life activities of parasites.This review mainly describes the progress of research about GST on parasites and provides insights for the related research.

关 键 词：寄生虫 谷胱甘肽转移酶(GST) 功能 药物靶点 

分 类 号：S852.7[农业科学—基础兽医学]