早期先兆流产患者血清激素水平及孕囊、胚芽与保胎结局的关系研究  

Study on the correlation between serum hormone levels, gestational sac, embryo, and outcomes of fetal protection in patients with early threatened abortion

作　　者：张贺 唐开 ZHANG He;TANG Kai(Department of Obstetrics and Gynecology,Dalian Women and Children’s Medical Center,Dalian 116000,China)

机构地区：[1]辽宁省大连市妇女儿童医疗中心妇产科,116000

出　　处：《中国实用医药》2021年第1期41-43,共3页China Practical Medicine

摘　　要：目的对早期先兆流产患者血清激素水平及孕囊、胚芽与保胎结局的关系进行研究。方法178例早期先兆流产患者,依据保胎结局不同分为保胎失利组(67例)和保胎顺利组(111例)。比较两组孕4、6、8周各项血清激素指标[β-人绒毛膜促性腺激素(β-HCG)、血清糖链蛋白125(CA125)、血清泌乳素(PRL)、甲胎蛋白(AFP)、雌二醇(E2)、孕酮(P)]水平及孕囊直径、胚芽长度。结果孕4、6、8周,保胎顺利组β-HCG、PRL、AFP、E2、P水平均高于保胎失利组,CA125水平低于保胎失利组,差异具有统计学意义(P<0.05)。孕4、6、8周,保胎顺利组孕囊直径分别为(1.64±0.62)、(3.28±0.83)、(4.14±0.62)cm,胚芽长度分别为(0.65±0.52)、(1.82±0.69)、(2.32±0.51)cm,均大于保胎失利组的(0.98±0.41)、(1.71±0.56)、(2.58±1.24)cm和(0.62±0.51)、(0.70±0.59)、(1.32±0.19)cm,差异具有统计学意义(P<0.05)。结论早期先兆流产患者的保胎结局与各项血清激素水平有关,早期先兆流产保胎顺利患者β-HCG、PRL、E2、P水平均高于保胎失利患者,CA125水平低于保胎失利患者,孕囊、胚芽均较保胎失利患者更大。Objective To study the correlation between serum hormone levels,gestational sac,embryo,and outcomes of fetal protection in patients with early threatened abortion.Methods A total of 178 patients with early threatened abortion were divided into failure group(67 cases)and success group(111 cases)according to different outcomes of fetal protection.The serum hormone indicators[β-human chorionic gonadotropin(β-HCG),serum carbohydrate antigen 125(CA125),serum prolactin(PRL),alpha-fetoprotein(AFP),estradiol(E2),progesterone(P)]levels,gestational sac diameter and embryo length at 4,6,and 8 weeks of pregnancy were compared between the two groups.Results At 4,6,and 8 weeks of pregnancy,the levels ofβ-HCG,PRL,AFP,E2 and P of success group were higher than failure group,and CA125 was lower than failure group,and the difference was statistically significant(P<0.05).At 4,6,and 8 weeks of pregnancy,gestational sac diameter[(1.64±0.62),(3.28±0.83),(4.14±0.62)cm]and embryo length[(0.65±0.52),(1.82±0.69),(2.32±0.51)cm]of success group were longer than those of failure group[(0.98±0.41),(1.71±0.56),(2.58±1.24)cm and(0.62±0.51),(0.70±0.59),(1.32±0.19)cm],and the difference was statistically significant(P<0.05).Conclusion The outcome of fetal protection in patients with early threatened abortion is correlated to the levels of various serum hormones.The levels ofβ-HCG,PRL,E2,and P in patients with successful miscarriage protection is higher than those of failure miscarriage protection,the level of CA125 is lower than patients with failure miscarriage protection,and gestational sac and germ are longer than those of patients with failure miscarriage protection.

关 键 词：先兆流产 血清激素 孕囊 胚芽 保胎 

分 类 号：R714.21[医药卫生—妇产科学]