不同性别、临床科室患者血小板抗体筛查结果分析  

Analysis of platelet antibody screening results in patients with different gender and clinical departments

作　　者：陆乐[1] 李平[1] 刘婷婷 王树亚 周勤 LU Le;LI Ping;LIU Tingting;WANG Shuya;ZHOU Qin(Department of Blood Transfusion,Gulou Hospital Affiliated to Medical College of Nanjing University,Nanjing,Jiangsu 210008,China;School of Mathematics and Statistics,Jiangsu Normal University,Xuzhou,Jiangsu 221116,China)

机构地区：[1]南京大学医学院附属鼓楼医院输血科,江苏南京210008 [2]江苏师范大学数学与统计学院,江苏徐州221116

出　　处：《国际检验医学杂志》2021年第3期263-265,269,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(11671178);江苏省输血协会英科新创科研基金项目(Js2018028)。

摘　　要：目的调查血小板抗体在住院患者中的阳性率,分析血小板抗体在性别之间的差异及在临床科室的分布情况,从而进一步保障临床患者输注血小板的有效性与安全性。方法选取2019年3-5月在南京大学医学院附属鼓楼医院有输血可能的入院患者8250例作为研究对象,采用固相凝集法检测其血小板抗体。计算抗体阳性率,并利用R3.4.1软件进行统计分析。结果女性患者的血小板抗体阳性率(6.60%)显著高于男性患者(4.43%),差异有统计学意义(P<0.05)。聚类分析结果显示风湿免疫科、血液内科和中医科患者的血小板抗体阳性率显著高于其他临床科室,差异有统计学意义(P<0.05)。结论女性患者及血液病、风湿免疫疾病患者应重视血小板抗体筛查,以便阳性患者在血小板输注前进行血小板交叉配型,避免出现血小板输注无效。Objective To investigate the positive rate of platelet antibody in hospitalized patients,analyze the difference of platelet antibody between genders and the distribution of clinical departments,so as to further ensure the effectiveness and safety of platelet transfusion in clinical patients.Methods A total of 8250 hospitalized patients with the possibility of blood transfusion in Gulou Hospital Affiliated to Medical College of Nanjing University from March to May 2019 were selected as the research objects,and their platelet antibodies were detected by solid phase agglutination method.The antibody positive rate was calculated and analyzed by R3.4.1 software.Results The positive rate of platelet antibody in female patients(6.6%)was significantly higher than that in male patients(4.43%),the difference was statistically significant(P<0.05).The results of cluster analysis showed that,the positive rate of antibody in rheumatology department,hematology department and traditional Chinese medicine department was significantly higher than that in other departments,the difference was statistically significant(P<0.05).Conclusion Female patients and patients with hematologic diseases and rheumatic immune diseases should pay attention to platelet antibody screening,so that positive patients can carry out platelet cross matching before platelet transfusion to avoid ineffective platelet transfusion.

关 键 词：固相凝集法 血小板抗体 血小板输注无效 输血安全 

分 类 号：R446.6[医药卫生—诊断学]