阻塞性睡眠呼吸暂停综合征患者血浆γ-氨基丁酸、内皮素1水平与认知功能障碍的关系  

Relationships between plasma gamma-aminobutyric acid,endothelin 1 levels and cognitive impairment in patients with obstructive sleep apnea syndrome

作　　者：陈锋[1] 苏娴[1] 陈惠[2] 王月宾[1] 梁秋萍[1] 吴迪[1] 严方涛 李群[1] CHEN Feng;SU Xian;CHEN Hui;WANG Yue-bin;LIANG Qiu-ping;WU Di;YAN Fang-tao;LI Qun(Department of Respiratory and Critical Care Medicine,Chengdu Institute of Respiratory Health,Chengdu Third People′s Hospital,Chengdu 610031,China;Department of Otolaryngology,Chengdu Third People′s Hospital,Chengdu 610031,China)

机构地区：[1]四川省成都市第三人民医院呼吸与危重症医学科(成都市呼吸健康研究所),成都市610031 [2]四川省成都市第三人民医院耳鼻喉科,成都市610031

出　　处：《广西医学》2020年第24期3175-3178,共4页Guangxi Medical Journal

基　　金：四川省成都市卫计委科研课题(2016026)。

摘　　要：目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者血浆γ-氨基丁酸(GABA)、内皮素1水平与认知功能障碍(CI)的关系。方法将116例OSAS患者根据是否发生CI分为有CI组和无CI组,各58例,另取60例体检健康者为对照组。采用酶联免疫吸附法检测各组血浆GABA、内皮素1水平,采用简易精神状况评定表(MMSE)及蒙特利尔认知功能评估量表(MoCA)评估OSAS患者的认知功能,分析OSAS患者血浆GABA、内皮素1水平与CI的关系。结果(1)对照组、无CI组、有CI组血浆GABA水平依次降低,内皮素1水平依次升高(均P<0.05)。(2)有CI组的MMSE评分和MoCA评分均低于无CI组(均P<0.05)。(3)有CI组血浆GABA水平与MMSE评分、MoCA评分均呈正相关,血浆内皮素1水平与MMSE评分、MoCA评分均呈负相关(均P<0.05)。(4)Logistic回归分析结果显示,低MMSE评分、低MoCA评分、低血浆GABA水平、高血浆内皮素1水平是OSAS患者发生CI的危险因素。结论OSAS患者血浆中GABA呈低表达,内皮素1呈高表达,二者是OSAS患者发生CI的危险因素,可能与OSAS患者发生CI有关。Objective To explore the relationships of plasma gamma-aminobutyric acid(GABA)and endothelin 1(ET-1)levels with cognitive impairment(CI)in patients with obstructive sleep apnea syndrome(OSAS).Methods A total of 116 OSAS patients were divided into CI group(n=58)and non-CI group(n=58)according to the presence of CI,and another 60 healthy check-up individuals were enrolled as control group.Enzyme-linked immunosorbent assay was used to detect plasma GABA and ET-1 levels in each group,the Mini-Mental Status Evaluation(MMSE)and the Montreal Cognitive Assessment(MoCA)were employed to assess the cognitive function of patients with OSAS,and the relationships of plasma GABA and ET-1 levels with CI were analyzed in patients with OSAS.Results(1)Plasma GABA level decreased and ET-1 level increased in the order of the control group,the non-CI group and the CI group(all P<0.05).(2)The CI group had lower MMSE score and MoCA score than the non-CI group(all P<0.05).(3)In the CI group,plasma GABA level positively correlated with MMSE score and MoCA score,while plasma ET-1 level negatively correlated with MMSE score and MoCA score(all P<0.05).(4)Logistic regression analysis results showed that low MMSE score,low MoCA score,low plasma GABA level,and high plasma ET-1 level were the risk factors for developing CI in OSAS patients.Conclusion Low expression of plasma GABA and high expression of plasma ET-1 are observed in OSAS patients,which are the risk factors for developing CI in OSAS patients,and may be related to the occurrence of CI in OSAS patients.

关 键 词：阻塞性睡眠呼吸暂停综合征 Γ-氨基丁酸 内皮素1 认知功能障碍 危险因素 

分 类 号：R562.1[医药卫生—呼吸系统]