慢性阻塞性肺疾病急性加重期炎性细胞因子与肺功能的相关性  

Correlation of Pulmonary Function of Inflammatory Cytokines in Acute Exacerbation of COPD

作　　者：刘杨[1] 陆佳 朴阳[2] LIU Yang;LU Jia;PIAO Yang(Department of Geriatric Respiration,Heilongjiang Provincial Hospital,Harbin Heilongjiang 150036,China;Department of Science and Education,Heilongjiang Provincial Hospital,Harbin Heilongjiang 150036,China)

机构地区：[1]黑龙江省医院老年呼吸科,黑龙江哈尔滨150036 [2]黑龙江省医院科教科,黑龙江哈尔滨150036

出　　处：《中国卫生标准管理》2021年第2期38-40,共3页China Health Standard Management

基　　金：黑龙江省卫计委科研课题(2018180)。

摘　　要：目的分析慢性阻塞性肺疾病急性加重期炎性细胞因子水平变化及与肺功能的相关性。方法对本院2019年3月—2020年3月收治的62例患者的炎性细胞因子进行检测,分析各项炎性细胞因子水平变化情况及其与患者肺功能之间的相关性。结果62例患者的IL-6指标、IL-8指标和TNF-α指标均随着患者综合评估分级的增加而增加,且各级比较存在明显差异(P<0.05);急性加重期患者的IL-6指标、IL-8指标和TNF-α指标均明显高于缓解期(P<0.05)。结论在COPD急性加重期患者的临床诊断中炎性细胞因子水平的变化情况可作为临床上重要的判断指标,能够直接对患者的肺功能和病情程度进行反应。Objective To analyze the changes of inflammatory cytokines in acute exacerbation stage of chronic obstructive pulmonary disease(COPD)and its correlation with pulmonary function.Methods The levels of inflammatory cytokines were measured in 62 patients from March 2019 to March 2020,and the correlation between the levels of inflammatory cytokines and pulmonary function was analyzed.Results The indexes of IL-6,IL-8 and TNF-αin 62 patients increased with the increase of comprehensive evaluation and grading(P<0.05);the indexes of IL-6,IL-8 and TNF-αin patients with acute exacerbation were significantly higher than those in patients with remission(P<0.05).Conclusion In the clinical diagnosis of COPD patients with acute exacerbation,which can directly respond to the lung function and the degree of disease.

关 键 词：慢性阻塞性肺疾病 急性 加重期 炎性细胞因子 肺功能 相关性 

分 类 号：R563[医药卫生—呼吸系统]