2014~2019年郑州大学第一附属医院血培养分离病原菌临床分布及耐药性分析  

Clinical Distribution and Antibiotic Resistance of the Blood Cultureisolates from the First Affiliated Hospital of Zhengzhou University,2014~2019

作　　者：徐慧[1] 徐岷[1] 刘彩林[1] 李晓改 王红梅[1] 叶亚菲[1] 曾利[1] XU Hui;XU Min;LIU Cai-lin;LI Xiao-gai;WANG Hong-mei;YE Ya-fei;ZENG Li(Department of Clinical Laboratory,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院检验科,郑州450052

出　　处：《现代检验医学杂志》2021年第1期136-140,共5页Journal of Modern Laboratory Medicine

摘　　要：目的了解郑州大学第一附属医院血培养病原菌的构成及耐药性。方法回顾性分析郑州大学第一附属医院2014年1月~2019年12月间临床血培养分离的13456株细菌药敏结果,按照CLSI2019年标准,使用WHONET 5.6软件进行数据分析。结果血培养分离前5位的细菌分别为大肠埃希菌3121株(23.2%)、凝固酶阴性葡萄球菌2822株(21.0%)、肺炎克雷伯菌2038株(15.1%)、金黄色葡萄球菌844株(6.3%)和屎肠球菌727株(5.4%)。大肠埃希菌对亚胺培南、厄他培南的耐药率分别为3.7%和4.2%。肺炎克雷伯菌对亚胺培南、厄他培南的耐药率分别为43.5%和47.6%。鲍曼不动杆菌对大多数测试抗生素耐药性高,而铜绿假单胞菌对大多数抗生素保持较高的敏感性。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为42.1%和84.2%,未发现万古霉素耐药的金黄色葡萄球菌。结论郑州大学第一附属医院血培养分离细菌耐药情况较为严重,临床应合理应用抗生素,主动开展细菌耐药性监测,遏制细菌耐药性的上升。Objective To investigate the distribution and antibiotic resistance of clinical isolates from blood culture in the First Affiliated Hospital of Zhengzhou University.Methods A total of 13456 clinical strains collected from blood cultures in the First Affiliated Hospital of Zhengzhou University from Jun 2014 to Dec 2019 were analyzed retrospectively.The data were analyzed by WHONET 5.6 software according to the Clinical and Laboratory Standards Institute(CLSI)2019 breakpoints.Results The top five populations of the bacteria isolates were E.coli(23.2%),coagulase negative Staphylococci(21.0%),K.pneumoniae(15.1%),S.aureus(6.3%)and E.faecium(5.4%),respectively.The resistance rates of E.coli isolates to imipenem and meropenem were 3.7%and 4.2%,respectively.However,the resistance rates of K.pneumoniae isolates to imipenem and meropenem were 43.5%and 47.6%,respectively.Most of the tested antimicrobial agents revealed poor activity against A.baumannii isolates but good activity against P.aeruginosa isolates.The prevalence of methicillin resistant S.aureus(MRSA)and methicillin resistant coagulase negative Staphylococcus(MRCNS)were 42.1%and 84.2%,respectively.No vancomycin resistant S.aureus isolates were found.Conclusion The antimicrobial resistance of clinical isolates of blood cultures from the First Affiliated Hospital of Zhengzhou University was severe.Promoting the rational use of antimicrobial agents and conducting bacterial resistance surveillance actively should be strengthento prevent the increase of the bacteria drug resistance.

关 键 词：血培养 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学] R446.5[医药卫生—基础医学]