新型感染标志物在脓毒症早期诊断中的应用及研究进展  

Latest Research Progress of Early Serum Inflammatory and Oxidative Stress Mediator of Sepsis

作　　者：张晨[1] 孙虹佳[1] ZHANG Chen;SUN Hong-jia(Department of Clinical Laboratory,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院检验科,兰州730000

出　　处：《现代检验医学杂志》2021年第1期156-160,共5页Journal of Modern Laboratory Medicine

基　　金：甘肃省自然科学基金(项目编号:20JR10RA680)。

摘　　要：脓毒症(sepsis)是感染引起宿主反应失调,导致危及生命的器官功能障碍症候群,病情危急,死亡率高。血培养是诊断的金标准,但培养及鉴定时间较长,而临床治疗需要在脓毒症早期杀灭病原菌以控制患者病情,提高治愈率,减少用药时间,降低死亡率。因此,迫切需要能够快速、准确诊断早期脓毒症的实验室指标以指导临床抗生素治疗。血清炎性介质和氧化应激介质是近年来发展起来的对判断早期感染有益的实验室指标,能够帮助临床医生快速判断感染的存在以及推断可能感染病原体的类型。快速诊断早期脓毒症对早期给药和制定抗菌治疗方案很重要。最终,这可能会提高患者生存率和治疗质量,并且减少抗生素耐药性的产生。Sepsis is a life-threatening organ dysfunction caused by the body’s uncontrolled response to infection,with critical conditions and high mortality.Blood culture is the gold standard for diagnosis,but it takes a long time for culture and identification.The clinical treatment requires the elimination of pathogenic bacteria at the early stage of sepsis to improve the cure rate,reduce the time of medication and the death rate.Therefore,laboratory indicators which can diagnose early sepsis quickly and accurately are urgently needed to guide clinical antimicrobial therapy.Serum inflammatory mediators and oxidative stress mediators have been developed in recent years,which are beneficial laboratory indicators for early infection judgment,and can help clinicians quickly judge the presence of infection and infer the type of pathogens that may be infected.Rapid diagnosis of early sepsis is important for early administration and antimicrobial therapy.Ultimately,this may improve patient survival and quality of treatment and reduce antimicrobial resistance.

关 键 词：脓毒症 血清炎性介质 氧化应激介质 16S~23S rRNA基因 

分 类 号：R631[医药卫生—外科学] R446[医药卫生—诊断学]