组蛋白去乙酰化酶调控软骨细胞终末分化的机制  

The mechanism of histone deacetylase regulating terminal differentiation of chondrocytes

作　　者：许博洋 王可欣 金宇 王驰宇 郭义[6,8,9] XU Boyang;WANG Kexin;JIN Yu;WANG Chiyu;GUO Yi(School of Acupuncture-Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Institute of Sports Medicine,Peking University,Beijing 100191,China;Beijing Key Laboratory of Sports Medicine Joint Injuries,Beijing 100191,China;School of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Traditional Chinese Medicine,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;School of Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Electrical Engineering and Computer Sciences,University of California,Berkeley,CA 94720-1776,America;Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;National Clinical Research Center of Traditional Chinese Medicine and Acupuncture,Tianjin 300381,China)

机构地区：[1]天津中医药大学针灸推拿学院,天津301617 [2]北京大学运动医学研究所,北京100191 [3]北京市运动医学关节伤病重点实验室,北京100191 [4]天津中医药大学中药制药工程学院,天津301617 [5]云南中医药大学中药学院,云南昆明650500 [6]天津中医药大学中医学院,天津301617 [7]美国南加州大学伯克利分校工程学院电子工程与计算机科学系,加利福尼亚州CA 94720-1776 [8]天津中医药大学实验针灸学研究中心,天津301617 [9]国家中医针灸临床医学研究中心,天津300381

出　　处：《中国医学物理学杂志》2021年第2期233-237,共5页Chinese Journal of Medical Physics

基　　金：国家自然科学基金重点项目(81330088);国家级大学生创新创业训练项目(201910063002);大学生科技创新基金项目(CXJJ2019YC06)。

摘　　要：终末分化是软骨细胞获得分化的默认途径,包括肥大与凋亡两种方式。无论是在骨组织生理条件下的软骨生长板形成及内源性成骨骨化,还是骨关节炎病理情况时的软骨表型改变,皆存在有相关分化过程的发生。组蛋白去乙酰化酶对于软骨细胞的生长、维持和增殖方面具有重要意义。它可通过调节基因表达和激活相关转录因子的方式介导某些疾病的发展,但目前其具体的分子生物学和生物力学机制仍不明确。本文将从生物物理学角度对组蛋白去乙酰化酶在软骨组织终末分化过程中的参与机制以及对于软骨组织工程应用价值进行总结和讨论。Terminal differentiation is the default pathway for chondrocytes to differentiate,which include hypertrophy and apoptosis.Whether it is cartilage growth plate formation under bone physiological conditions and endogenous cartilage osteogenesis,or cartilage phenotypic changes in the pathological condition of osteoarthritis,there is a related differentiation process.Histone deacetylases are important for the growth,maintenance and proliferation of chondrocytes.They mediate the development of certain diseases by regulating gene expression and activating related transcription factors.However,their specific molecular biology and biomechanical mechanisms are still unclear.In this paper,the participation mechanism of histone deacetylases in the terminal differentiation of cartilage tissue and the application value of cartilage tissue engineering will be summarized and discussed from the perspective of biophysics.

关 键 词：组蛋白去乙酰化酶 软骨细胞 终末分化 综述 

分 类 号：R35[医药卫生—基础医学]