度洛西汀联合益生菌治疗腹泻型肠易激综合征的疗效观察  

Observation on the effect of duloxetine combined with probiotics in the treatment of diarrheal irritable bowel syndrome

作　　者：石伟 SHI Wei(First Aid Station of Shenyang Taoxian International Airport Co.,Ltd.,Shenyang 110169,China)

机构地区：[1]沈阳桃仙国际机场应急救援中心急救站,110169

出　　处：《中国实用医药》2021年第2期32-34,共3页China Practical Medicine

摘　　要：目的探讨度洛西汀联合益生菌治疗腹泻型肠易激综合征(IBS)的疗效。方法107例腹泻型IBS患者,按交替分组法分为观察组(54例)和对照组(53例)。对照组患者给予双歧杆菌三联活菌胶囊口服治疗,观察组在对照组的基础上给予度洛西汀胶囊治疗。比较两组患者临床疗效以及治疗前后的脑肠肽指标、精神状态评分。结果观察组治疗总有效率90.74%高于对照组的71.70%,差异具有统计学意义(P<0.05)。治疗后,两组患者血管活性肠肽(VIP)、5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)、P物质(SP)水平均低于治疗前,且观察组患者VIP、5-HT、CGRP、SP水平分别为(0.22±0.13)ng/ml、(48.92±5.14)ng/ml、(77.42±7.65)pg/ml、(52.34±5.82)pg/ml,均低于对照组的(0.33±0.18)ng/ml、(78.64±7.82)ng/ml、(82.64±8.51)pg/ml、(75.67±7.58)pg/ml,差异均具有统计学意义(P<0.05)。治疗后,两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于治疗前,且观察组SAS评分(30.50±3.24)分、SDS评分(32.50±3.52)分均低于对照组的(38.00±3.78)、(39.00±3.83)分,差异均具有统计学意义(P<0.05)。结论度洛西汀联合益生菌治疗腹泻型IBS,能有效降低患者脑肠肽水平,改善患者焦虑、抑郁情绪,治疗效果显著。Objective To discuss the efficacy of duloxetine combined with probiotics in the treatment of diarrheal irritable bowel syndrome(IBS).Methods A total of 107 patients with diarrheal IBS were divided into observation group(54 cases)and control group(53 cases)according to alternate grouping method.Patients in the control group were treated with Bifidobacterium triple viable capsules orally,and patients in the observation group were treated with duloxetine capsules on the basis of the control group.The clinical efficacy,brain-gut peptide index and mental state score before and after treatment were compared between the two groups.Results The total effective rate of treatment 90.74%of the observation group was higher than 71.70%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT),calcitonin gene-related peptide(CGRP),substance P(SP)of the two groups were lower than those before treatment,and VIP(0.22±0.13)ng/ml,5-HT(48.92±5.14)ng/ml,CGRP(77.42±7.65)pg/ml and SP(52.34±5.82)pg/ml of the observation group were all lower than(0.33±0.18)ng/ml,(78.64±7.82)ng/ml,(82.64±8.51)pg/ml and(75.67±7.58)pg/ml of the control group,and the difference was statistically significant(P<0.05).After treatment,the self-rating anxiety scale(SAS)and self-rating depression scale(SDS)score of the two groups were lower than those before treatment,and SAS score(30.50±3.24)and SDS score(32.50±3.52)points of the observation group were lower than(38.00±3.78)and(39.00±3.83)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Duloxetine combined with probiotics has a significant therapeutic effect in the treatment of diarrhea IBS,which can effectively reduce the brain-gut peptide levels of patients,improve patients’anxiety and depression.

关 键 词：腹泻型肠易激综合征 度洛西汀 益生菌 疗效 

分 类 号：R574[医药卫生—消化系统]