马来酸曲美布汀胶囊联合益生菌治疗肠易激综合征的效果探讨  

Effect of trimebutine maleate capsules combined with probiotics in the treatment of irritable bowel syndrome

作　　者：赵丽娟 武建军 张慧敏 张春凤 ZHAO Li-juan;WU Jian-jun;ZHANG Hui-min(Department of Gastroenterology,People’s Hospital of Inner Mongolia Autonomous Region,Hohhot 010010,China)

机构地区：[1]内蒙古自治区人民医院消化内科,010010

出　　处：《中国实用医药》2021年第2期35-37,共3页China Practical Medicine

摘　　要：目的探讨马来酸曲美布汀胶囊联合益生菌治疗肠易激综合征的效果。方法106例肠易激综合征患者,根据治疗方法不同分为对照组和观察组,每组53例。对照组患者单纯采用马来酸曲美布汀胶囊进行治疗,观察组患者采用马来酸曲美布汀胶囊联合益生菌进行治疗。比较两组患者临床治疗效果、治疗前后诺丁汉健康描述表(NHP)评分、治疗后生活质量评分,并分析两组患者不良反应发生情况。结果观察组患者临床总有效率96.23%显著高于对照组的81.13%,差异具有统计学意义(P<0.05)。两组均未出现严重的不良反应,个别患者出现口干、头昏情况,在停药之后好转,没有进行特殊干预。治疗前,两组患者NHP评分比较差异无统计学意义(P>0.05);治疗后,观察组NHP评分(27.64±3.31)分明显低于对照组的(36.11±3.34)分,差异具有统计学意义(P<0.05)。治疗后,观察组躯体功能、社会功能、心理功能、物质功能评分均优于对照组,差异具有统计学意义(P<0.05)。结论肠易激综合征患者采用马来酸曲美布汀胶囊联合益生菌方案治疗,相对于单纯采用马来酸曲美布汀胶囊治疗的患者,可以取得更好的治疗效果,值得推荐患者选用。Objective To discuss the effect of trimebutine maleate capsules combined with probiotics in the treatment of irritable bowel syndrome.Methods A total of 106 patients with irritable bowel syndrome were divided into control group and observation group according to different treatment methods,with 53 cases in each group.The control group was treated with trimebutine maleate capsules,and the observation group was treated with trimebutine maleate capsules combined with probiotics.The clinical effect,Nottingham Health Profile(NHP)score before and after treatment,and quality of life score after treatment were compared between the two groups,and the occurrence of adverse reactions in the two groups was analyzed.Results The total clinical effective rate of the observation group 96.23%was significantly higher than 81.13%of the control group,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in the two groups.Individual patients experienced dry mouth and dizziness,which improved after stopping the drug without special intervention.Before treatment,there was no statistically significant difference in NHP score between the two groups(P>0.05).After treatment,NHP score(27.64±3.31)points of the observation group was obviously lower than(36.11±3.34)points of the control group,and the difference was statistically significant(P<0.05).After treatment,the physical function,social function,mental function,material function score of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with patients treated with trimebutine maleate capsules alone,trimebutine maleate capsules combined with probiotics can better improve the therapeutic effect of patients with irritable bowel syndrome,which is worthy of recommendation.

关 键 词：肠易激综合征 马来酸曲美布汀胶囊 益生菌 效果 

分 类 号：R574.4[医药卫生—消化系统]