毛囊及相关干细胞在创面无瘢痕愈合中的研究进展  

Research progress of hair follicle and related stem cells in scar-free wound healing

作　　者：周圳滔 赵沁园 赵钧 张菊芳 ZHOU Zhentao;ZHAO Qinyuan;ZHAO Jun;ZHANG Jufang(The Fourth Clinical College of Zhejiang Chinese M edicine University,Hangzhou Zhejiang,310013,P.R.China;Department of Plastic Surgery,A ffiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang,310006,P.R.China;Nanjing M edical University,Nanjing Jiangsu,211100,P.R.China)

机构地区：[1]浙江中医药大学附属第四临床医学院,杭州310013 [2]浙江大学医学院附属杭州市第一人民医院整形外科,杭州310006 [3]南京医科大学,南京211100

出　　处：《中国修复重建外科杂志》2021年第2期241-245,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：2020年杭州市卫生健康科技计划项目(Z20200127)。

摘　　要：目的综述毛囊及相关干细胞在创面无瘢痕愈合中的研究进展。方法广泛查阅近年国内外毛囊及相关干细胞与创面愈合及瘢痕形成的相关文献,从细胞功能及分子机制等方面进行总结讨论。结果创面经毛囊及相关干细胞移植治疗愈合后形成的瘢痕更轻微,甚至无瘢痕形成。上述现象涉及的细胞种类及分子机制复杂,目前主要明确了与BMP信号通路及Wnt信号通路强相关。结论毛囊及相关干细胞在创面无瘢痕愈合方面的研究尚处于起步阶段,需要加强机制研究,以期为创面和瘢痕的治疗提供新思路。Objective To explore the research progress of hair follicle and related stem cells in scar-free skin healing in recent years. Methods The literature related to hair follicle and related stem cells, wound healing, and scar formation in recent years was extensively reviewed and summarized from the aspects of cell function and molecular mechanism. Results Scar tissue after wound healing treated with hair follicle transplantation and related stem cell therapy is more mild or even without scar formation. The cell types and molecular mechanisms of the above phenomena are complex, and the bone morphogenetic protein signal transduction pathway and Wnt signal transduction pathway are strongly correlated. Conclusion The research of hair follicle and related stem cells in scar-free skin healing is at the initial stage at present. Strengthening the mechanism research may provide new ideas for the treatment of wound and scar.

关 键 词：毛囊 毛囊干细胞 毛乳头细胞 真皮鞘细胞 创面愈合 瘢痕形成 

分 类 号：R641[医药卫生—外科学]