外泌体对脊髓损伤修复作用的研究进展  

Research progress in exosomes in repair of spinal cord injury

作　　者：陈建[1] 赵书杰 武梦圆 周正 汪肖玮 凡进[1] 殷国勇[1] Chen Jian;Zhao Shujie;Wu Mengyuan;Zhou Zheng;Wang Xiaowei;Fan Jin;Yin Guoyong(Department of Orthopedics,First Afiliated Haspital of Narjing Medical University(Jiangsu Prorincial,People's Hospital),Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院(江苏省人民医院)骨科,210029

出　　处：《中华创伤杂志》2021年第1期85-92,共8页Chinese Journal of Trauma

基　　金：国家自然科学基金(81520108018,81772351,81902211);江苏省科技社会发展计划重大项目(BE2017755);江苏省自然科学青年基金(BK20191061)。

摘　　要：脊髓损伤是常见的脊柱骨折合并伤,可导致患者运动及感觉功能障碍甚至瘫痪。外泌体作为纳米级的细胞微粒参与多种疾病的发生与发展,已受到广泛关注。脊髓损伤时来源于脊髓组织细胞的外泌体对损伤进程与组织修复产生影响;另外,外泌体可作为脊髓损伤的一种新兴治疗方案也被广为研究。笔者就脊髓组织中各类细胞外泌体在脊髓损伤中的作用机制以及多种细胞来源外泌体在脊髓损伤中的修复作用进行综述,加深对外泌体在脊髓损伤中作用的认识,为研究脊髓损伤病程和治疗提供新思路。Spinal cord injury is a common clinical disease secondary to spinal cord fractures that causes patients with motor and sensory dysfunction or even paralysis.In recent years,exosomes have participated in the occurrence and development of various diseases as nanometer-sized cell particles,and have received extensive attention.Exosomes derived from spinal cord tissue cells during spinal cord injury affect the injury process and tissue repair.In addition,exosomes as a new treatment for spinal cord injury have been widely studied.The authors document the mechanisms of various exosomes from spinal cord tissue and the repair effects of various cell-derived exosomes in spinal cord injury,in order to deepen the understanding of the role of exosomes in spinal cord injury and provide new ideas for studying the course and treatment of spinal cord injury.

关 键 词：脊髓损伤 外泌体 信息传导 

分 类 号：R651.2[医药卫生—外科学]