神经酰胺的功能及其在肺动脉高压中的作用  

Functions of ceramide and its role in pulmonary arterial hypertension

作　　者：李发美 余再新[1] LI Fa-mei;YU Zai-xin(Department of Cardiovascular Medicine,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院心血管内科,湖南长沙410008

出　　处：《基础医学与临床》2021年第2期267-271,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81873416)。

摘　　要：神经酰胺是一种鞘磷脂分子,作为细胞内第二信使,调控细胞增殖、分化、衰老和凋亡等生命活动。肺动脉高压是一类以肺小动脉重构和肺血管阻力增加为特征的疾病,神经酰胺通过介导肺血管重构、炎性反应过程和产生脂毒性参与肺动脉高压的发生、发展。了解神经酰胺的生物学功能及其参与肺动脉高压发生发展的具体机制,有助于给肺动脉高压的治疗提供新思路。Ceramide is a kind of sphingomyelin molecule,as a second messenger in cells,regulates cell proliferation,differentiation,senescence,apoptosis and other life activities.Pulmonary arterial hypertension is a disease characterized by pulmonary arterioles remodeling and increased increased vascular resistance.Ceramide is involved in the occurrence and development of pulmonary arterial hypertension by mediating pulmonary vascular remodeling,inflammatory response and lipotoxicity.Understanding the biological functions of ceramide and its mechanism involved in the development of pulmonary arterial hypertension may provide new idea for the treatment of pulmonary arterial hypertension.

关 键 词：神经酰胺 合成与代谢 生物学功能 肺动脉高压 

分 类 号：Q545.3[生物学—生物化学] R543.2[医药卫生—心血管疾病]