微流控芯片技术在药物化学实验中的应用  

Application of microfluidic chip technology in pharmaceutical chemistry experiment

作　　者：高志刚[1] 罗勇[1] 宋其玲[1] 李悦青[1] 王世盛[1] 叶俊伟[1] GAO Zhigang;LUO Yong;SONG Qiling;LI Yueqing;WANG Shisheng;YE Junwei(National Chemical Engineering Comprehensive Experimental Teaching Demonstration Center,School of Chemical Engineering,Dalian University of Technology,Dalian 116024,China)

机构地区：[1]大连理工大学化工学院国家级化工综合实验教学示范中心,辽宁大连116024

出　　处：《实验技术与管理》2020年第12期72-74,79,共4页Experimental Technology and Management

基　　金：2016年辽宁省教育教学改革研究与实践项目;大连理工大学教学改革基金项目(YB2016052)。

摘　　要：微流控技术是对微米尺度空间的微流体进行操作的技术。因具有自动化程度高、灵活性高、可集成、高效、低成本、高分辨率、高灵敏度等优势,故在常规化学合成和生物化学等方面有广泛的应用前景。该文以药物化学创新实验教学改革为研究背景,基于简易搭建微通道反应装置,以邻硝基苯甲醛、乙酰乙酸甲酯为原料合成硝苯地平原料药。对氮源的种类、反应物的配比、流速控制、反应温度等实验条件进行优化,收率可达到85%以上。该方法具有连续制备、反应时间短、收率高、装置价格便宜等优点,拓展了微流控技术在药物化学合成实验教学中的应用。Microfluidic technology is a technique for operating microfluidics in micron-scale spaces.Due to its advantages such as the integration,low cost,automation,flexibility,efficient resolution,sensitivity,etc.,which has broad application prospects in conventional chemistry and biochemistry.In this paper,based on the background of teaching reform of pharmaceutical chemistry innovation experiment and the simple construction of micro channel reaction device,the nifedipine is synthesized from o-nitrobenzaldehyde and methyl acetoacetate.The experimental conditions such as the type of nitrogen source,ratio of reactants,flow rate control and reaction temperature are optimized,and the yield can reach more than 85%.This method has the advantages of continuous preparation,short reaction time,high yield and low cost,which expands the application of microfluidic technology in experimental teaching of pharmaceutical chemical synthesis.

关 键 词：微流控技术 药物化学实验 硝苯地平的合成 

分 类 号：O621[理学—有机化学]