血液病患者血流感染病原菌回顾性分析  

Pathogens in Bloodstream Infection in Patients with Hematological Diseases:Retrospective Analysis

作　　者：王茂全 贾明宇 靖彧[2] 于力 WANG Mao-Quan;JIA Ming-Yu;JING Yu;YU Li(School of Medicine,Nankai University,Tianjin 300071,China;Department of Hematology,General Hospital of PLA,Beijing 100853,China)

机构地区：[1]南开大学医学院,天津300071 [2]中国人民解放军总医院血液科,北京100853

出　　处：《中国实验血液学杂志》2021年第1期272-277,共6页Journal of Experimental Hematology

摘　　要：目的:分析解放军总医院血液科患者血流感染的主要病原菌的分布,并观察其耐药性,为临床医师的早期合理用药提供依据。方法:选取2014年1月至2017年12月212例患者286例次送检血培养阳性标本,分析患者的基本临床特征及感染病原菌的种类分布。结果:革兰阴性菌182株(63.64%)、革兰阳性菌104株(36.36%)。培养结果主要为:大肠埃希菌88株(30.77%)、铜绿假单胞菌34株(11.89%)、肺炎克雷伯菌26株(9.09%)、表皮葡萄球菌25株(8.74%)、革兰阳性杆菌20株(6.99%)、人葡萄球菌16株(5.59%)、溶血葡萄球菌11株(3.85%)、金黄色葡萄球菌10株(3.50%)、头状葡萄球菌6株(2.10%)、鲍曼不动杆菌5株(1.75%)等。革兰阴性菌中大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌对阿米卡星敏感性较高,革兰阳性菌中表皮葡萄球菌、人葡萄球菌对万古霉素、呋喃妥因敏感性较高。结论:我院血液科血流感染患者中血培养结果革兰阴性菌较多,临床上应用抗菌药物时应参考细菌培养及药敏试验结果。Objective:To analyze the distribution and drug resistance of pathogens sampled from the patients with bloodstream infection in the department of hematology of PLA General Hospital,so as to provide evidences for clinical prevention and control infection.Methods:From January 2014 to December 2017,A total of 286 cases-time positive blood culture samples from 212 patients in the department of hematology of the General Hospital of Chinese PLA were collected.The clinical characteristics of patients and the distribution and drug resistance of pathogens were analyzed retrospectively.Results:182(63.64%) bacterial strains were Gram-negative,and the other 104(36.36%) were Grampositive.There were 88 strains of Escherichia coli(30.77%),34 strains of Pseudomonas aeruginosa(11.89%),26 strains of Klebsiella pneumoniae(9.09%),25 strains of Staphylococcus epidermidis(8.74%),20 strains of Grampositive rods(6.99%),16 strains of Staphylococcus hominis(5.59%),11 strains of Etaphylococcus haemolyticus(3.85%),10 strains of Staphylococcus aureus(3.50%),6 strains of Staphylococcus capitis(2.10%),5 strains of Acinetobacter baumannii(1.75%) and so on.Escherichia coli,Pseudomonas aeruginosa and Klebsiella pneumoniae as Gram-negative bacteria were sensitive to amikacin.Staphylococcus epidermidis and Staphylococcus aureus as Grampositive bacteria were sensitive to vancomycin and nitrofurantoin.Conclusion:The blood culture patients with bloodstream infection in department of hematology of our hospital confirmed that more infections are Gram-negative.The clinicians should choose suitable antibiotics according to the results of bacterial culture and drug sensitive test.

关 键 词：血流感染 血液病 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学] R733[医药卫生—基础医学]