国际输血协会3个新增红细胞血型系统研究的回顾(2019)  

Three Novel Blood Group Systems Registered by ISBT in 2019——Review

作　　者：何克宇 徐婧 张敏[1] HE Ke-Yu;XU Jing;ZHANG Min(Blood Transfusion Department,Zhongda Hospital,Southeast University,Nanjing 210009,Jiangsu Province,China)

机构地区：[1]东南大学附属中大医院输血科,江苏南京210009

出　　处：《中国实验血液学杂志》2021年第1期283-287,共5页Journal of Experimental Hematology

基　　金：江苏省自然科学基金(BK20180376);中央高校基本科研业务费专项资金(2242020K40174)。

摘　　要：国际输血协会(ISBT)在2019年8月注册了3个全新的血型系统:KANNO血型系统、Sid血型系统、CTL2血型系统(待定)。ISBT此次更新的主要原因是,2019年研究者们通过全基因组关联研究和全外显子组测序,先后发现了KANNO血型系统(rs1800014)和Sid血型系统(rs7224888)表面抗原的重要单核苷酸多态性(SNP)位点,获得了这2种血型系统的遗传学证据支持,其结果也与目前的免疫学研究结论相一致。此外,虽然研究者在2017年首次发现红细胞血影(细胞膜)上也存在CTL2抗原,但由于缺少血清学和遗传学证据,CTL2血型系统目前仍为待定状态。本文将回顾这3个ISBT新增血型系统的实验研究进程,论述相关研究的临床意义。There were three new blood group systems including the KANNO blood group system,the Sid blood group system and the CTL2 blood group system(provisional status),have been registered by the International Society of Blood Transfusion(ISBT)registered Science August 2019.The main reason for this update is that the significant SNPs of the KANNO blood group system(rs1800014)and the Sid blood group system(rs7224888)have been found through genome-wide association studies and whole exome sequencing.The new genetic evidences are consistent with the current immunological findings.In addition,although CTL2 antigen has been found on erythrocyte ghost(erythrocyte membrane)since 2017,CTL2 blood group system is still in provisional status due to lack of serological and genetic evidence.In this review,the experimental research advances of these three ISBT blood group systems and discuss the clinical value of the relevant researches was summarized briefly.

关 键 词：血型系统 KANNO1抗原 Sd^a抗原 CTL2抗原 

分 类 号：R457[医药卫生—治疗学]