妇科患者人乳头瘤病毒感染特点及基因分型  

Characteristics and genotypes of human papillomavirus infection in Gynecology patients

作　　者：祁青玲[1] 王乾印 贾佳 高文君 王烈宏[1] QI Qing-ling;WANG Qian-yin;JIA Jia;WANG Zu-chun;GAO Wen-Jun;WANG Lie-hong(Qinghai Red Cross Hospital.Gynecology,Xining,China 810000)

机构地区：[1]青海红十字医院妇产科,青海西宁810000

出　　处：《中国病原生物学杂志》2020年第11期1353-1356,1362,共5页Journal of Pathogen Biology

摘　　要：目的分析妇科患者人乳头瘤病毒感染特点及基因分型情况,指导临床抗感染防治。方法收集妇科患者宫颈内分泌物,采用核酸分子快速导流杂交基因芯片技术,检测HPV及基因分型。对患者临床资料及HPV感染情况,卡方检验进行统计学分析。结果315例妇科患者,感染患者数60例,感染率19.05%。20~35岁、36~45岁、46~55岁妇科患者HPV感染率分别为12.77%、28.43%、15.97%。妇科患者中,宫颈糜烂、尖锐湿疣、宫颈炎及其他宫颈疾病患者HPV感染率分别为28.13%、19.54%、16.35%、13.33%。首次性生活年龄<18岁、性伴侣个数≥2个、性生活频率4次/周以上的妇科患者HPV感染率明显高于其他患者。妊娠次数在≥2次、分娩方式为剖宫产的妇科患者感染率明显高于其他患者。受教育程度为大学以下、月收入<3000元/月的妇科患者HPV感染率明显高于其他患者。经卡方检验,差异均有统计学意义(P<0.05)。妇科患者HPV单一感染率为61.67%,多重感染率为38.33%,差异显著。单一HPV感染类型中,高危型感染率56.67%,低危型感染率5.00%,差异显著;多重HPV感染类型中,二重感染率35.00%,三重感染率3.33%,差异显著。妇科患者发生HPV单重感染中,HPV16为主要型别,HPV18型次之;妇科患者发生HPV多重感染类型以HPV 16+HPV 18居多,HPV 16+HPV 39、HPV 16+HPV 33次之。结论年龄、宫颈疾病类型、性生活特点、妊娠次数、分娩方式、受教育程度及经济状况都是影响妇科患者HPV感染的因素。妇科患者感染HPV类型以高危型为主,部分患者发生多重感染,应引起临床重视。Objectives To analyze the characteristics and genotypes of human papillomavirus infection in Gynecology patients in order to guide the clinical prevention and treatment of infections.Methods Cervical secretions were collected from Gynecology patients,and HPV was genotyped using flow-through nucleic acid hybridization and gene chip technology.The clinical data on and the HPV infection status of patients were statistically analyzed using software and the chisquare test.Results Of 315 Gynecology patients,60 had an infection,for a rate of infection of 19.05%.The rate of infection with HPV was 12.77%in Gynecology patients ages 20-35,28.43%in patients ages 36-45,and 15.97%in patients ages 46-55.The rate of infection with HPV was 28.13%in Gynecology patients with cervical erosion,19.54%in patients with condyloma acuminatum,16.35%in patients with cervicitis,and 13.33%in patients with some other cervical condition.Gynecology patients who were younger than 18 at first sexual intercourse,who had 2 or more sexual partners,and who had sexual intercourse more than 4 times per week had a significantly higher rate of infection with HPV than other patients.Gynecology patients who had 2 or more pregnancies or who underwent a cesarean section had a significantly higher rate of infection than other patients.Gynecology patients with less than a university education and who earned less than 3,000 yuan/month had a significantly higher rate of infection with HPV than other patients.The chi-square test revealed significant differences between Gynecology patients and other patients(P<0.05).Age,cervical condition,age at first sexual intercourse,number of sexual partners,frequency of sexual intercourse,number of pregnancies,method of delivery,level of education,and economic status were all factors affecting HPV infection in Gynecology patients.The rate of a single infection with HPV was 61.67%in Gynecology patients,and the rate of multiple infections was 38.33%,indicating a significant difference.In patients with a single HPV infection,the

关 键 词：妇科患者 人乳头瘤病毒 HPV感染 基因分型 

分 类 号：R373.9[医药卫生—病原生物学]