口服营养补充对老年慢性病伴营养不良人群营养指标及免疫功能的影响  

Effects of oral nutritional supplementation on nutrition indexes and immune function of elderly patients with chronic diseases and malnutrition

作　　者：朱永飞 刘娜[2] 姚飞 刘伟 ZHU Yongfei;LIU Na;YAO Fei;LIU Wei(Department of Nutrition,Henan General Hospital,Zhengzhou 450000,Henan,China;Department of Pharmacy,Zhengzhou First People's Hospital,Zhengzhou 450000,Henan,China)

机构地区：[1]河南省职工医院营养科,河南郑州450000 [2]河南省郑州市第一人民医院药剂科,河南郑州450000

出　　处：《右江医学》2021年第1期62-65,共4页Chinese Youjiang Medical Journal

摘　　要：目的探究口服营养补充对老年慢性病伴营养不良人群营养指标以及免疫功能的影响。方法选取于2018年9月至2019年9月诊治的老年慢性病伴营养不良住院患者100例,采用随机数字表将其分为对照组和观察组,各50例。对照组给予普食干预,观察组在对照组基础上给予口服营养补充干预,两组均干预3个月。比较两组患者干预前后营养指标、免疫功能指标以及胃肠黏膜屏障功能相关指标的差异性,并评价安全性。结果两组患者的体重指数(BMI)、三头肌皮褶厚度(TSF)以及血红蛋白(Hb)干预前后均无统计学意义(P>0.05),观察组干预后的上臂围(MAC)、白蛋白(ALB)、前白蛋白(PAB)均显著高于对照组(P<0.01)。观察组干预后的CD3+、CD4+以及CD4+/CD8+较干预前明显升高(P<0.05),且均显著高于对照组(P<0.01)。两组干预后的二胺氧化酶(DAO)及尿L/M值均明显低于干预前(P<0.01),且观察组干预后的DAO以及尿L/M值均显著低于对照组(P<0.05)。两组不良反应发生率分别为8.00%和12.00%,差异无统计学意义(P>0.05)。结论老年慢性病伴营养不良人群给予口服营养补充,有助于改善患者机体营养状况,提高机体免疫功能和肠黏膜屏障功能,安全系数较高。Objective To explore the effects of oral nutritional supplementation on nutrition indexes and immune function of elderly patients with chronic diseases and malnutrition. Methods A total of 100 elderly inpatients with chronic diseases and malnutrition who were diagnosed and treated in the hospital from September 2018 to September 2019 were enrolled. They were divided into control group and observation group by random number table, with 50 cases in each group. The control group were given general diets intervention, and based on which the observation group were given oral nutrition supplement intervention. Both groups were intervened for 3 months. And then, differences in nutrition indexes, immune function indexes and related indexes of gastrointestinal mucosal barrier function before and after intervention were compared between two groups, and the safety was evaluated. Results Before and after intervention, there was no statistically significant differences in body mass index(BMI), triceps skin fold(TSF) and hemoglobin(Hb) between the two groups(P > 0.05). After intervention, mid-arm circumference(MAC), albumin(ALB) and prealbumin(PAB) in the observation group were all significantly higher than those in the control group(P < 0.01). After intervention, CD3~+, CD4~+ and CD4~+/CD8~+ were significantly increased in observation group(P < 0.05), which were significantly higher than those in the control group(P < 0.01). After intervention, diamine oxidase(DAO) and urine L/M in both groups were significantly decreased(P < 0.05), which were significantly lower in the observation group than in the control group(P < 0.01). The incidence of adverse reactions in the two groups was 8.00% and 12.00%, respectively, difference was not statistically significant(P > 0.05). Conclusion Oral nutritional supplements for the elderly with chronic diseases and malnutrition are conductive to improving nutrition status, immune functions and intestinal mucosal barrier functions with high safety factor.

关 键 词：口服营养补充 慢性病 营养不良 老年 营养指标 免疫功能 

分 类 号：R459.3[医药卫生—治疗学]