匹伐他汀钙片联合阿司匹林治疗冠心病高脂血症的临床效果  

Clinical effect of Pitavastatin Calcium Tablets combined with Aspirin in the treatment of coronary heart disease with hyperlipidemia

作　　者：童早英 TONG Zao-ying(Department of Cardiology,Dexing People′s Hospital,Jiangxi Province,Dexing334200,China)

机构地区：[1]江西省德兴市人民医院心内科,江西德兴334200

出　　处：《中国当代医药》2021年第3期83-86,共4页China Modern Medicine

基　　金：江西省上饶市科技计划项目(20192CKJ21)。

摘　　要：目的探讨匹伐他汀钙片联合阿司匹林治疗冠心病高脂血症的临床效果。方法选取2018年3月~2020年2月于德兴市人民医院接受治疗的93例冠心病高脂血症患者作为研究对象,依据盲抽法将其分为对照组(n=46)与观察组(n=47)。两组患者均予以常规治疗,对照组予以匹伐他汀钙片治疗,观察组在对照组基础上加用阿司匹林治疗。比较两组的临床疗效、血脂指标及不良反应总发生率。结果观察组患者的临床疗效优于对照组,且观察组患者的总有效率(97.87%)高于对照组(82.61%),差异有统计学意义(P<0.05);治疗后,观察组患者的总胆固醇(TC)[(1.56±0.37)mmol/L]、三酰甘油(TG)[(3.13±0.54)mmol/L]、低密度脂蛋白胆固醇(LDL-C)[(2.19±0.36)mmol/L]均低于治疗前[(4.38±1.01)、(6.49±1.52)、(5.24±1.01)mmol/L],差异有统计学意义(P<0.05);对照组患者治疗后的TC[(2.31±0.47)mmol/L]、TG[(4.61±0.98)mmol/L]、LDL-C[(3.28±0.49)mmol/L]均低于治疗前[(4.36±1.03)、(6.51±1.48)、(5.33±1.05)mmol/L],差异有统计学意义(P<0.05);观察组患者治疗后的高密度脂蛋白胆固醇(HDL-C)[(2.03±0.34)mmol/L]高于治疗前[(0.86±0.13)mmol/L],对照组患者治疗后的HDL-C[(1.56±0.28)mmol/L]高于治疗前[(0.85±0.12)mmol/L],差异有统计学意义(P<0.05);且观察组患者治疗后的TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应总发生率(6.38%)与对照组(13.04%)比较,差异无统计学意义(P>0.05)。结论冠心病高脂血症患者采用匹伐他汀钙片联合阿司匹林治疗的效果显著,可有效改善患者的血脂指标,促进其身体转归,且安全性高。Objective To investigate the clinical effect of Pitavastatin Calcium Tablets combined with Aspirin in the treatment of coronary heart disease with hyperlipidemia.Methods Altogether 93 patients who had coronary heart disease with hyperlipidemia treated in Dexing People′s Hospital from March 2018 to February 2020 were selected as subjects and divided into control group(n=46)and observation group(n=47)according to the blind drawing method.The two groups were given conventional treatment,the control group was treated with Pitavastatin Calcium Tablets,while the observation group was treated with Aspirin on the basis of the control group.The clinical efficacy,blood lipid indexes and total incidence of adverse reactions were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group,and the total effective rate of the observation group(97.87%)was higher than that of the control group(82.61%),with statistically significant differences(P<0.05).After treatment,the levels of total cholesterol(TC)([1.56±0.37]mmol/L),triacylglycerol(TG)([3.13±0.54]mmol/L),low density lipoprotein cholesterol(LDL-C)([2.19±0.36]mmol/L)in the observation group were lower than those before treatment([4.38±1.01],[6.49±1.52],[5.24±1.01]mmol/L),the differences were statistically significant(P<0.05).The levels of TC([2.31±0.47]mmol/L),TG([4.61±0.98]mmol/L),LDL-C([3.28±0.49]mmol/L)in the control group after treatment were lower than those before treatment([4.36±1.03],[6.51±1.48],[5.33±1.05]mmol/L),the differences were statistically significant(P<0.05).The high density lipoprotein cholesterol(HDL-C)of the observation group after treatment was(2.03±0.34)mmol/L,which was higher than that before treatment([0.86±0.13]mmol/L),the HDL-C of the control group after treatment was(1.56±0.28)mmol/L,which was higher than that before treatment([0.85±0.12]mmol/L),the differences were statistically significant(P<0.05).And the levels of TC,TG and LDL-C of the observation group after

关 键 词：冠心病高脂血症 匹伐他汀钙片 阿司匹林 血脂指标 

分 类 号：R969.4[医药卫生—药理学]