PA-aO2、PaCO2和Lac水平与急性百草枯中毒患者的预后的相关性  

Correlation of PA-aO2,PaCO2 and Lac levels with prognosis of patients with acute paraquat poisoning

作　　者：康莹 刘玉环 王华丽 KANG Ying;LIU Yuhuan;WANG Huali(Emergency Department,Central Hospital of Zhumadian,Zhumadian,Henan,China,463000;Radiotherapy Department,Central Hospital of Zhumadian,Zhumadian,Henan,China,463000)

机构地区：[1]河南省驻马店市中心医院急诊科,河南驻马店463000 [2]河南省驻马店市中心医院放疗科,河南驻马店463000

出　　处：《分子诊断与治疗杂志》2021年第1期51-54,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省卫生厅基金项目(20190418)。

摘　　要：目的探究肺泡-动脉氧分压差(PA-aO2)、动脉血二氧化碳分压(PaCO2)和血乳酸(Lac)水平与急性百草枯中毒(APP)患者的预后的相关性。方法选取2018年8月至2020年8月就诊于本院的126例APP患者,根据3个月随访情况,分为存活组57例和死亡组69例,另选取同期于本院进行健康体检的健康人群45例作为对照组,检测3组PA-aO2、PaCO2和Lac水平。结果与对照组比较,APP患者PA-aO2和Lac水平显著升高,PaCO2水平显著降低,且死亡组变化幅度显著大于存活组,差异有统计学意义(P<0.05);PA-aO2和Lac与存活组呈负相关,与死亡组呈正相关,PaCO2与存活组呈正相关,与死亡组呈负相关(P<0.05);PA-aO2、PaCO2和Lac联合检测对APP患者预后的预测价值显著高于单一指标,差异有统计学意义(P<0.05)。结论PA-aO2、PaCO2和Lac水平与APP患者预后密切相关,值得临床参考。Objective To explore the correlation between the difference of Alveolar arterial oxygen partial pressure(PA-aO2),arterial carbon dioxide tension(PaCO2)and blood lactic acid(Lac)levels and the prognosis of patients with acute paraquat poisoning(APP).Methods 126 cases of APP patients in our hospital from August 2018 to August 2020 were selected and divided into survival group(57 cases)and death group(69 cases)according to the 3-month follow-up.Another 45 healthy people who had physical examination in our hospital during the same period were selected as the control group.The levels of PA-aO2,PaCO2 and Lac in the three groups were detected.Results Compared with the control group,the levels of PA-aO2 and Lac in app patients were significantly higher than those in the survival group,and the changes of PaCO2 in the death group were significantly greater than those in the survival group,and the difference was statistically significant(P<0.05);PA-aO2 and Lac were negatively correlated with the survival group,and positively correlated with the death group;PaCO2 was positively correlated with the survival group,and negatively correlated with the death group;the combined detection of pa-ao2,PaCO2 and Lac could predict the prognosis of APP patients.The predictive value of the latter was significantly higher than that of single index,and the difference was statistically significant(P<0.05).Conclusion PA-aO2,PaCO2 and Lac levels are closely related to the prognosis of APP patients and are worthy of clinical reference.

关 键 词：肺泡-动脉氧分压差 动脉血二氧化碳分压 血乳酸 急性百草枯中毒 

分 类 号：R595.4[医药卫生—内科学]