慢性心力衰竭合并糖尿病患者血浆BNP、CRP和HbA1c的表达及与心功能分级的相关性  

Expression of plasma BNP,CRP and HbA1c in patients with chronic heart failure combined with diabetes and its correlation with classification of cardiac function

作　　者：白兴合[1] 代玉川[1] 刘平[2] 王艳玲[3] 王磊[2] BAI Xinghe;DAI Yuchuan;LIU Ping;WANG Yanling;WANG Lei(Department of Cardiology,Affiliated Hospital of Jining Medical College,Jining,Shandong,China,272029;Department of Medical Imaging,Affiliated Hospital of Jining Medical College,Jining,Shandong,China,272029;Department of Neurology,Affiliated Hospital of Jining Medical College,Jining,Shandong,China,272029)

机构地区：[1]济宁医学院附属医院心内科,山东济宁272029 [2]济宁医学院附属医院医学影像科,山东济宁272029 [3]济宁医学院附属医院神经内科,山东济宁272029

出　　处：《分子诊断与治疗杂志》2021年第1期119-122,127,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山东省重点研发计划项目(2019GSF118251)。

摘　　要：目的分析慢性心力衰竭(CHF)合并糖尿病患者血浆脑钠肽(BNP)、C-反应蛋白(CRP)和糖化血红蛋白(HbA1c)的表达及与心功能分级的相关性。方法选取本院2019年4月至2020年10月收治且经临床确诊的144例CHF合并糖尿病患者作为研究组,心功能分级:Ⅱ级48例,Ⅲ级60例,Ⅳ36例。同期纳入90例本院门诊健康体检者作为对照组。比较不同组别血浆BNP、CRP和HbA1c水平,并分析上述因子水平与CHF合并糖尿病患者心功能的相关性。结果研究组血浆BNP、CRP、HbA1c水平及LVEDVI显著高于对照组,LVEF显著低于对照组,差异有统计学意义(P<0.05)。Ⅱ级组、Ⅲ级组、Ⅳ级组血浆BNP、CRP、HbA1c水平及LVEDVI均显著高于对照组,LVEF显著低于对照组,差异有统计学意义(P<0.05)。随着心功能下降,血浆BNP、CRP、HbA1c水平及LVEDVI逐渐上升,LVEF逐渐下降(P<0.05);BNP、CRP、HbA1c与LVEDVI呈显著正相关,与LVEF呈显著负相关,与心功能分级呈显著正相关(P<0.05)。结论CHF合并糖尿病患者的血浆BNP、CRP、HbA1c水平均明显上升,且与其心功能分级具有一定相关性,通过检测上述因子水平可有效评估患者心功能。Objective To analyze the expression of plasma brain natriuretic peptide(BNP),C-reactive protein(CRP)and HaemoglobinA1c(HbA1c)in patients with chronic heart failure(CHF)combined with diabetes and its correlation with classification of cardiac function.Methods 144 patients with CHF and diabetes who were admitted to this hospital from April 2019 to October 2020 and were diagnosed by the clinic were selected as the research objects and included in the study group.The cardiac function classification is as follows:48 cases in gradeⅡ,60 cases in gradeⅢ,36 cases in gradeⅣ.In the same period,90 cases with healthy physical examination in the outpatient department of this hospital were included as the control group.The levels of BNP,CRP and HbA1c in different groups were compared,and the correlation between the levels of these factors and the cardiac function of patients with CHF and diabetes was analyzed.Results The levels of plasma BNP,CRP,HbA1c and LVEDVI in the study group were significantly higher than those in the control group,and the LVEF was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of BNP,CRP,HbA1c and LVEDVI in the gradeⅡ,ⅢandⅣgroups were significantly higher than those in the control group,and the LVEF was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).With the declining of heart function,plasma BNP,CRP,HbA1c levels and LVEDVI gradually increased,and LVEF gradually decreased(P<0.05).BNP,CRP,HbA1c were positively correlated with LVEDVI,negatively correlated with LVEF,and positively correlated with classification of cardiac function(P<0.05).Conclusion The levels of plasma BNP,CRP,and HbA1c in patients with CHF and diabetes mellitus have been significantly increased,and have a certain correlation with with their cardiac function classification.The detection of the levels of the above factors can effectively assess the cardiac function of patients.

关 键 词：慢性心力衰竭合并糖尿病 血浆脑钠肽 C-反应蛋白 糖化血红蛋白 心功能 

分 类 号：R587.2[医药卫生—内分泌] R541.6[医药卫生—内科学]