糖浆联合西替利嗪对过敏性咳嗽患儿血清总IgE、IgA及补体C3水平的影响  

Effect of Xikening Syrup combined with cetirizine on serum total IgE,IgA and complement C3 levels in children with allergic cough

作　　者：万斌[1] 何淼 郭春艳 WAN Bin;HE Miao;GUO Chunyan(Department of Pediatrics,Shiyan People's Hospital Affiliated to Hubei Medical University,Shiyan,Hubei,China,442000;Department of Pediatrics,Baihe Hospital of Traditional Chinese Medicine,Ankang City,Shanxi Province,Ankang,Shanxi,China,725800)

机构地区：[1]湖北医药学院附属十堰市人民医院儿科,湖北十堰442000 [2]陕西省安康市白河县中医院儿科,陕西安康725800

出　　处：《分子诊断与治疗杂志》2021年第1期156-159,共4页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省自然科学基金项目(2018CFB412)。

摘　　要：目的探究过敏性咳嗽患儿采用息可宁糖浆联合西替利嗪的治疗疗效。方法选择本院2018年6月至2019年6月期间收治的156例过敏性咳嗽患儿为研究对象,按照随机数字表分组要求将患儿分为对照组(n=78)与联合组(n=78),对照组予息可宁糖浆治疗,联合组在对照组基础上加用西替利嗪。比较两组患儿治疗前后临床症状评分,血清中总免疫球蛋白E(IgE)、IgA及补体C3水平,治疗效果与复发频率,咳嗽相关时间,安全性。结果两组患儿治疗后日间、夜间咳嗽评分以及VAS评分较治疗前改善,差异具有统计学意义(P<0.05),治疗后联合组患儿上述临床症状评分高于对照组,差异具有统计学意义(P<0.05);与治疗前比较,两组患儿治疗后血清中总IgE水平下降,总IgA与补体C3水平上升,前后比较差异具有统计学意义(P<0.05),治疗后联合组患儿血清中总IgE水平显著低于对照组,总IgA与补体C3水平高于对照组,差异具有统计学意义(P<0.05);联合组患儿咳嗽减少、夜间以及日间咳嗽停止时间等咳嗽相关症状改善时间短于对照组,差异具有统计学意义(P<0.05);联合组患儿治疗总有效率高于对照组,差异具有统计学意义(P<0.05),联合组患儿复发频率低于对照组,差异具有统计学意义(P<0.05);联合组与对照组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论过敏性咳嗽患儿采用息可宁糖浆联合西替利嗪治疗可以有效改善患儿咳嗽相关临床症状,降低患儿复发频率,纠正血清总IgE、IgA及补体C3紊乱水平,治疗效果显著。Objective To explore the curative effect of Xikening Syrup combined with cetirizine in children with allergic cough.Methods A total of 156 children with allergic cough who were admitted and treated in the hospital between June 2018 and June 2019 were selected as the research subjects.They were divided into control group(n=78)and combined group(n=78)according to random number table.The control group was treated with Xikening Syrup,and the combined group was treated with Xikening Syrup combined with cetirizine.The clinical symptom scores,serum total immunoglobulin(Ig)E,IgA and complement component 3 levels,treatment effect,recurrence frequency,cough-related time and safety were compared between the 2 groups.Results After treatment,daytime and nighttime cough scores and VAS scores of both groups were improved(P<0.05),and the above-mentioned clinical symptom scores of combined group were higher than those of the control group(P<0.05).After treatment,serum total IgE levels were decreased,while total IgA and complement C3 levels were increased in both groups(P<0.05).Besides,serum total IgE levels were lower in combined group than those in the control group,and total IgA and complement C3 levels were higher than those in the control group(P<0.05).The improvement time of cough-related symptoms was shorter in the combined group than the control group(P<0.05).The total response rate of the combined group was higher than that of the control group(P<0.05),and the recurrence frequency was lower in the combined group than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion The treatment with Xikening Syrup combined with cetirizine for children with allergic cough can effectively improve the cough-related clinical symptoms,reduce recurrence frequency,and correct serum total IgE,IgA and complement C3 disorders,with significant therapeutic effect.

关 键 词：息可宁糖浆 西替利嗪 过敏性咳嗽 

分 类 号：R725.6[医药卫生—儿科]