芪参益气滴丸对急性心肌梗死患者经皮冠状动脉介入术后心功能及血清脑钠肽、肿瘤坏死因子-α、C反应蛋白、白细胞介质-6及白细胞介质-10水平影响  

Effect of Qishen Yiqi Dropping Pill on cardiac function and serum levels of NT-pro brain natriuretic peptide,tumor necrosis factor-α,C-reactive protein,interleukin-6 and interleukin-10 in patients with acute myocardial infarction after percutaneous coronary intervention

作　　者：解娟[1] 王潇[2] 张永强 甄利波[1] 赵晨祎 姚海珍[1] 张欣欣[1] 许巧玲[1] XIE Juan;WANG Xiao;ZHANG Yong-qiang;ZHEN Li-bo;ZHAO Chen-yi;YAO Hai-zhen;ZHANG Xin-xin;XU Qiao-ling(Department of Cardiology,the first Central Hospital of Baoding City,Baoding 071000,China)

机构地区：[1]河北省保定市第一中心医院心内四科,河北保定071000 [2]河北省保定市第一中心医院科教科,河北保定071000 [3]河北省保定市第一中心医院医务科,河北保定071000

出　　处：《创伤与急危重病医学》2021年第1期41-44,共4页Trauma and Critical Care Medicine

基　　金：保定市科技计划项目(1951ZF065)。

摘　　要：目的探讨芪参益气滴丸对急性心肌梗死患者经皮冠状动脉介入(PCI)术后心功能及血清脑钠肽(NT-proBNP)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介质-6(IL-6)及白细胞介质-10(IL-10)水平的影响。方法选取自2018年1月至2020年1月收治的PCI术治疗的112例急性心肌梗死患者为研究对象。根据随机数字表法将患者分为A组和B组,每组各56例。A组在PCI术后采取常规治疗,B组在A组治疗的基础上,加用芪参益气滴丸,观察两组患者血清NT-proBNP、TNF-α、CRP、IL-6及IL-10水平变化,心功能的改善情况及临床疗效。结果治疗后,两组患者的NT-proBNP、TNF-α、CRP、IL-6及IL-10水平均优于治疗前,且B组各指标的改善程度优于A组,差异均有统计学意义(P<0.05)。治疗后,两组患者的左心室舒张末期容积、左心室收缩末期容积及左心室射血分数水平均优于治疗前,且B组各指标的改善程度均优于A组,差异均有统计学意义(P<0.05)。B组患者的治疗有效率为85.7%(48/56),明显高于A组的75.0%(42/56),差异有统计学意义(P<0.05)。治疗期间,B组患者不良心血管事件的发生率为9.0%(5/56),明显低于A组的19.6%(11/56),两组间比较,差异有统计学意义(P<0.05)。结论芪参益气滴丸可有效改善急性心肌梗死患者PCI术后血清NT-proBNP、TNF-α、CRP、IL-6及IL-10水平,改善心功能,并有效降低心血管不良事件的发生。Objective To investigate the effect of Qishen Yiqi Dropping Pill on cardiac function and serum levels of NT-pro brain natriuretic peptide(NT-proBNP),Tumor Necrosis Factor(TNF)-α,C-Reactive protein(CRP),Interleukin-6(IL-6)and Interleukin-10(IL-10)in patients with acute myocardial infarction(AMI)after PCI.Methods A retrospective study was performed on 112 cases of patients with AMI who were admitted from January 2018 to January 2020.Patients were randomly divided into the Group A and Group B,with 56 cases in each group.Patients of Group A were performed convention treatment after PCI surgery,the others of Group B were added Qishen Yiqi Dropping Pill on the basis of treatment as the same in Group A,the changes of serum levels of NT-proBNP,TNF-α,CRP,IL-6 and IL-10,the improvement of cardiac function and clinical efficacy in both groups were observed.Results After treatment,the levels of NT-proBNP,TNF-α,CRP,IL-6 and IL-10 in both groups were better than those before treatment,and the improvement of each index in Group B was better than that in Group A,with statistically significant differences(P<0.05).After treatment,the left ventricular end-diastolic volume,left ventricular end-systolic volume and left ventricular ejection fraction in both groups were better than those before treatment,and the improvement degree of each index in Group B was better than that in Group A(P<0.05).The effective rate of Group B was 85.7%(48/56),which was significantly higher than that of Group A(75.0%,42/56),P<0.05.During treatment,the incidence of adverse cardiovascular events in Group B was 9.0%(5/56),which was significantly lower than that in Group A(19.6%,11/56),P<0.05.Conclusion Qishen Yiqi Dropping Pill can effectively improve serum levels of NT-proBNP,TNF-α,CRP,IL-6 and IL-10 in patients with acute myocardial infarction after PCI,improve cardiac function,and effectively reduce the occurrence of cardiovascular adverse events.

关 键 词：芪参益气滴丸 急性心肌梗死 经皮冠状动脉介入 心功能 炎症因子 

分 类 号：R542.2[医药卫生—心血管疾病]