盐酸帕罗西汀联合复方利多卡因乳膏治疗原发性早泄的短期疗效观察  

Short-term efficacy of paroxetine hydrochloride combined with compound lidocaine cream in the treatment of primary premature ejaculation

作　　者：张君俊[1] 杨祖佑[1] 杜春明 宋嘉胤 施东辉[1] ZHANG Junjun;YANG Zuyou;DU Chunming;SONG Jiayin;SHI Donghui(Department of Urology,Suzhou Wuzhong People′s Hospital,Suzhou,Jiangsu 215128,China)

机构地区：[1]苏州市吴中人民医院泌尿外科,江苏苏州215128

出　　处：《现代医药卫生》2021年第3期396-399,403,共5页Journal of Modern Medicine & Health

摘　　要：目的探讨盐酸帕罗西汀及复方利多卡因乳膏单独或联用治疗男性原发性早泄(PPE)的有效性和安全性。方法选取2018年1月至2020年1月在该院门诊采取3种不同治疗方法的PPE患者134例,年龄(31.45±5.35)岁,将其分为3组。A组42例性生活前30min按需利多卡因乳膏外涂龟头治疗8周;B组45例接受口服帕罗西汀20mg/d治疗4周后再按需口服4周;C组47例患者接受相同用法用量帕罗西汀联合利多卡因乳膏治疗8周。比较3组治疗方案治疗前和治疗后8周的临床总体印象变化(CGIC)、阴道内射精潜伏时间(IELT)、早泄诊断量表(PEDT)的变化及药物不良反应。结果 3组患者经治疗后其IELT均有好转,差异有统计学意义(P<0.001);C组IELT由(1.07±0.30)min延长至(5.04±2.57)min,与A、B组比较,差异均有统计学意义(P<0.05)。3组治疗后PEDT评分均有改善,差异有统计学意义(P<0.001);C组由(14.40±2.51)分变为(7.38±4.37)分,下降最明显,与A、B组比较,差异有统计学意义(P<0.05)。A、B、C组治疗总有效率分别为57.1%、64.4%、78.7%。C组与A组CGIC比较,差异有统计学意义(P<0.05),但C组与B组CGIC比较,差异无统计学意义(P>0.05)。不良反应方面主要为勃起不坚、过敏、头晕、恶心呕吐、纳差、腹泻,A、B、C组发生率分别为9.5%、11.0%、10.6%,3组比较,差异无统计学意义(P>0.05)。结论盐酸帕罗西汀联合利多卡因乳膏短期治疗PPE安全有效,可以显著延长患者射精潜伏期,改善性生活满意度,不良反应患者能耐受。Objective To investigate the efficacy and safety of paroxetine hydrochloride and compound lidocaine cream in the treatment of male primary premature ejaculation(PPE)alone or in combination.Methods A total of 134 patients with PPE who received three different treatment methods in the outpatient department from January 2018 to January 2020,aged(31.45±5.35)years old,were divided into three groups.Forty-two patients in group A received lidocaine cream on the balanus for 8 weeks as required.Forty-five patients in group B received oral paroxetine 20 mg/d for 4 weeks,followed by 4 weeks of oral administration as required.Forty-seven patients in group C received oral paroxetine combined with lidocaine cream on the balanus for 8 weeks.The changes in clinical general impression(CGIC),intraperitoneal ejaculation latency(IELT),premature ejaculation diagnostic scale(PEDT),and adverse drug reactions were compared before and 8 weeks after treatment.Results IELT improved after treatment in three groups,the differences were statistically significant(P<0.001);the IELT in group C was extended from(1.07±0.30)min to(5.04±2.57)min,which were statistically significant compared with the two groups A and B(P<0.05).In terms of PEDT evaluation,the three groups showed improvement after treatment,the differences were statistically significant(P<0.001),and the score of group C(14.40±2.51)points was changed to(7.38±4.37)points,with the most significant decline,which were statistically different from the two groups A and B(P<0.05).The total effective rates of A,B,C groups were 57.1%,64.4% and 78.7%.There was significant difference in CGIC between group C and group A(P<0.05),but there was no significant difference in CGIC between group C and group B(P>0.05).The main adverse reactions were erection difficulty,allergy,dizziness,nausea and vomiting,anorexia and diarrhea.The incidence rates of the A,B,C groups were 9.5%,11.0% and 10.6%,respectively,with no statistically significant difference(P>0.05).Conclusion Paroxetine hydrochloride combined

关 键 词：原发性早泄 盐酸帕罗西汀 复方利多卡因乳膏 治疗结果 

分 类 号：R698[医药卫生—泌尿科学]