血必净联合前列地尔治疗糖尿病肾病患者的临床效果  

Clinical Efficacy of Xubijing Combined with Alprostadil in the Treatment of Diabetic Nephropathy

作　　者：于淼 YU Miao(Dalian Fourth People's Hospital,Dalian 116000,China)

机构地区：[1]大连市第四人民医院,辽宁大连116000

出　　处：《中国医药指南》2021年第2期137-138,共2页Guide of China Medicine

摘　　要：目的探讨血必净联合前列地尔治疗糖尿病肾病患者的临床效果。方法选取我院2018年5月至2020年4月收治的84例糖尿病肾病患者,按照数字奇偶法分为观察组(42例,采用血必净+前列地尔治疗)和对照组(42例,采用前列地尔治疗)。比较两组生活质量、血肌酐(Scr)水平、24 h尿蛋白定量水平以及血尿素氮(BUN)水平。结果观察组患者的生命力、一般健康、社会功能、情感健康、机体疼痛、心理健康、躯体功能评分分别为(78.49±8.31)、(77.31±11.39)、(89.69±8.23)、(92.65±6.06)、(85.22±10.33)、(88.76±10.49)、(97.02±2.49)分,均高于对照组的(42.32±7.49)、(35.69±10.29)、(50.31±7.21)、(75.29±9.21)、(61.25±8.13)、(62.29±8.23)、(70.31±3.81)分,差异均有统计学意义(P <0.05);观察组患者Scr、24 h尿蛋白定量及BUN水平分别为(78.49±25.13)μmol/L、(0.59±0.22)g/24 h、(6.39±1.85)mmol/L,均低于对照组的(136.79±35.19)μmol/L、(1.11±0.49)g/24 h、(8.73±2.62)mmol/L,差异均有统计学意义(P <0.05)。结论血必净联合前列地尔的有效运用可实现糖尿病肾病患者生活质量的提升,显著降低Scr、24 h尿蛋白定量以及尿素氮水平,最终提升糖尿病肾病患者的预后效果。Objective To investigate the clinical efficacy of xubijing + alprostadil in the treatment of diabetic nephropathy patients. Methods A total of 84 patients with diabetic nephropathy admitted to our hospital from May 2018 to April 2020 were selected and divided into observation group(42 cases were treated with xuebijing and alprostadil) and control group(42 cases were treated with alprostadil) according to odd-even method. The quality of life, SCR level, 24 h urinary protein level and BUN level of blood urea nitrogen were compared between two groups. Results Treatment group patients with diabetic nephropathy vitality score(78.49±8.31) and general health score(77.31±11.39) points, social function score(89.69±8.23) points, emotional health score(92.65±6.06), the body pain score(85.22±10.33) points, mental health score(88.76±10.49), body function score(97.02±2.49) were significantly higher than the control group(42.32±7.49),(35.69±10.29),(50.31±7.21) points,(75.29±9.21) points,(61.25±8.13) points,(62.29±8.23) points,(70.31±3.81) points(P <0.05). The levels of Scr, 24 h urine protein quantification and BUN in the observation group were(78.49±25.13) μmol/L,(0.59±0.22) g/24 h, and(6.39±1.85) mmol/L, respectively, which were lower than those of the control group( 136.79±35.19) μmol/L,(1.11±0.49) g/24 h,(8.73±2.62) mmol/L, the differences were statistically significant(P<0.05). Conclusion The effective application of xubijing + alprostadil can significantly improve the quality of life of patients with diabetic nephropathy, and significantly reduce Scr score, urine protein quantitative level and BUN level at 24 h, finally achieving an effective prognosis of patients with diabetic nephropathy.

关 键 词：糖尿病肾病 血必净 前列地尔 生活质量 肌酐 24 h尿蛋白定量 

分 类 号：R587.2[医药卫生—内分泌]