蛋白质磷酸化对衣原体生理学影响的研究进展  

Progresses in impact of protein phosphorylation on chlamydial physiology

作　　者：Emmanuel Wirekoh ARTHUR 王英姿(综述) 周洲(指导)[1] Emmanuel Wirekoh ARTHUR;WANG Ying-Zi;ZHOU Zhou(Institution of Pathogenic Biology,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学病原微生物学研究所,衡阳421001

出　　处：《中国免疫学杂志》2021年第2期241-244,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(31570179);特殊病原体防控湖南省重点实验室资助项目(2014-5)。

摘　　要：衣原体是一类严格专性胞内寄生的原核细胞型微生物。蛋白质磷酸化是在细胞信号转导过程中起重要作用的一种蛋白质翻译后修饰方式,由蛋白质激酶和磷酸酶、双组分信号系统以及合作-开关机制3部分组成。蛋白质磷酸化可调节衣原体生理学过程,如代谢、发育、致病等。然而,由于衣原体特殊生长环境及研究方法的局限,介导和调节这些生理学过程的机制仍知之甚少。因此,本文就现阶段衣原体蛋白磷酸化及其在衣原体生理学方面的潜在作用进行综述。Chlamydia is a type of prokaryotic microorganisms that are strictly obligate intracellular parasitic.Protein phosphorylation is a post-translational modification method of protein that plays an important role in the process of cell signal transduction.It is composed of three parts:protein kinase and phosphatase,two-component signaling system,and cooperation-switch mechanism.Protein phosphorylation can regulate the physiological processes of Chlamydia,such as metabolism,development,and pathogenicity.However,due to the special growth environments and the limitations of research methods of Chlamydia,little is known about the mechanisms mediating and regulating these physiological processes.Therefore,this paper reviews the current chlamydial protein phosphorylation and its potential role in chlamydial physiology.

关 键 词：衣原体 蛋白质磷酸化 代谢 发育 致病机制 

分 类 号：R374[医药卫生—病原生物学]