细胞外核苷酸对免疫细胞的调节作用  

Regulatory effects of extracellular nucleotides on different immune cells

作　　者：王秋吉 杨启鑫 柴艳敏(指导) 单春华[1] WANG Qiu-Ji;YANG Qi-Xin;CHAI Yan-Min;SHAN Chun-Hua(College of Life Science,Northeast Forestry University,Harbin 150040,China)

机构地区：[1]东北林业大学生命科学学院,哈尔滨150040 [2]东北林业大学校医院,哈尔滨150040

出　　处：《中国免疫学杂志》2021年第2期249-253,共5页Chinese Journal of Immunology

基　　金：黑龙江省科学基金项目(No.C2016010)。

摘　　要：细胞释放到胞外空间的核苷酸称为胞外核苷酸,其浓度受多种水解酶调节,不同浓度的胞外核苷酸作用不同。胞外核苷酸及其衍生核苷与不同的嘌呤受体结合,激活复杂的信号传导网络,参与调控多种生理和病理过程,特别是胞外三磷酸腺苷(ATP)是免疫应答的关键介质,作为重要动态信号参与调控过程。本文综述了胞外核苷酸对巨噬细胞、树突状细胞(DCs)和淋巴细胞等免疫细胞的调节作用,并对胞外核苷酸在临床上的应用进行了展望。Objective:Nucleotides released into extracellular space is called extracellular nucleotides.Their concentrations are regulated by various hydrolytic enzymes.Extracellular nucleotides exert different effects depending on its concentration.Through binding to different purine receptors,extracellular nucleotides and their derivative nucleosides activate complex signal transduction networks and participate in regulating various physiological and pathological processes.Extracellular adenosine triphosphate(ATP),which is the key mediator of immune response,as an important dynamic signal involved in the regulation process.In this paper,the regulatory effects of extracellular nucleotides on immune cells such as macrophages,dendritic cells(DCs)and lymphocytes are reviewed,and the clinical application of extracellular nucleotides is prospected.

关 键 词：细胞外核苷酸 免疫细胞 嘌呤受体 

分 类 号：R392.1[医药卫生—免疫学]