血清免疫球蛋白E及超敏C反应蛋白检测在慢性阻塞性肺疾病诊断中的价值  

The value of plasma immunoglobulin E and hs-CRP in the diagnosis of chronic obstructive pulmonary disease

作　　者：徐斌 解晨曦[2] XU Bin;XIE Chenxi(Laboratory of Pathology,Armed Police Corps Hospital,Urumqi,Xingjiang 830063,China;Department of Clinical Laboratory,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xingjiang 830011,China)

机构地区：[1]武警兵团总队医院检验病理科,新疆乌鲁木齐830063 [2]新疆医科大学第五附属医院检验科,新疆乌鲁木齐830011

出　　处：《检验医学与临床》2021年第4期466-468,472,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清免疫球蛋白E(IgE)、超敏C反应蛋白(hs-CRP)检测在慢性阻塞性肺疾病(COPD)患者中的变化规律及各项指标之间的相关性。方法根据病情的诊断与分级,将2016年10月至2019年10月在武警兵团总队医院进行COPD治疗的230例患者分为观察A组[COPD急性加重期(AECOPD),162例]和观察B组(COPD稳定期,68例),选取同期体检健康者100例纳入对照组。比较3组的肺功能、IgE、hs-CRP水平,比较不同分级AECOPD患者间的IgE、hs-CRP水平,分析COPD患者各项指标间的相关性。结果IgE、hs-CRP水平在对照组、观察B组、观察A组间依次升高,差异有统计学意义(F=4.186,P=0.016;F=4.522,P=0.012),第1秒用力呼气容积占预计值百分比(FEV1%pre)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)在对照组、观察B组、观察A组间依次降低,差异有统计学意义(F=-3.572,P=0.030;F=-3.351,P=0.037)。AECOPDⅠ级、Ⅱ级、Ⅲ级患者IgE、hs-CRP水平依次升高,差异有统计学意义(F=-4.453,P=0.013;F=-4.652,P=0.011)。AECOPD患者中,肺功能分级与IgE、hs-CRP水平呈正相关(r=0.519,P=0.028;r=0.341,P=0.019)。COPD患者中,FEV1%pre与IgE、hs-CRP水平呈负相关(r=-0.653,P=0.031;r=-0.439,P=0.028);FEV1/FVC与IgE、hs-CRP水平呈负相关(r=-0.373,P=0.042;r=-0.392,P=0.017)。结论AECOPD、COPD稳定期患者的IgE、hs-CRP水平均明显升高,且会随着病情的加重而升高,IgE、hs-CRP对于COPD患者病情的准确评估具有指导意义。Objective To investigate the changes of serum immunoglobulin E(IgE),hypersensitive C reactive protein(hs-CRP)in patients with chronic obstructive pulmonary disease(COPD)and the correlations between these indexes.Methods A total of 230 patients with COPD treated from October 2016 to October 2019 in Armed Police Corps Hospital were collected and divided into observation group A[COPD acute exacerbation(AECOPD),162 cases]and observation group B(COPD stable period,68 cases)according to the diagnosis and classification of the disease.Meanwhile,100 cases of healthy subjects were included into control group.Lung function and IgE,hs-CRP levels were compared in the three groups.The IgE,hs-CRP levels in AECOPD patients with different pulmonary function grades were compared and the correlations between these indexes of COPD patients were analyzed.Results IgE,hs-CRP levels increased in control group,observation group B,observation group A,the differences were statistically significant(F=4.186,P=0.016;F=4.522,P=0.012).The FEV1%pre,FEV1/FVC decreased in control group,observation group B,observation group A,the differences were statistically significant(F=-3.572,P=0.030;F=-3.351,P=0.037).In AECOPD patients,IgE,hs-CRP levels increased with the pulmonary function grades,the differences were statistically significant(F=-4.453,P=0.013;F=-4.652,P=0.011).In AECOPD patients,pulmonary function positively correlated with IgE,hs-CRP level(r=0.519,P=0.028;r=0.341,P=0.019).In COPD patients,FEV1%pre negatively correlated with IgE,hs-CRP levels(r=-0.653,P=0.031;r=-0.439,P=0.028);FEV1/FVC negatively correlated with IgE,hs-CRP levels(r=-0.373,P=0.042;r=-0.392,P=0.017).Conclusion IgE and hs-CRP levels in patients with AECOPD and COPD stabilization significantly increase,and will rise as the disease worsens,both have guiding significance for the accurate evaluation of COPD patients′condition.

关 键 词：免疫球蛋白E 超敏C反应蛋白 慢性阻塞性肺疾病 

分 类 号：R446.6[医药卫生—诊断学]