2016-2018年德宏傣族景颇族自治州婚检人群HBV感染率及影响因素  

HBV prevalence and associated factors among persons receiving premarital medical examination in Dehong Dai and Jingpo Autonomous Prefecture during 2016-2018

作　　者：龚渝蓉 张晗希 唐树萍 杨世江 尹寿欢 杨跃诚 叶润华 王璐[2] 丁盈盈[4] 何纳[4] 段松 GONG Yu-rong;ZHANG Han-xi;TANG Shu-ping;YANG Shi-jiang;YIN Shou-huan;YANG Yue-cheng;YE Run-hua;WANG Lu;DING Ying-ying;HE Na;DUAN Song(Department of Sexual and AIDS Prevention Dehong Prefecture Center for Disease Control and Prevention,Mangshi 678400,China;Department of the Party and the Masses Affairs,National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Public Health Management Dehong Prefecture Center for Maternal and Child Care Service,Mangshi 678400,China;Department of Epidemiology,School of Public Health,Fudan University,Key Laboratory of Health Technology Assessment of Ministry of Health,Fudan University,Shanghai 200032,China)

机构地区：[1]云南德宏傣族景颇族自治州疾病预防控制中心性病艾滋病防制科,芒市678400 [2]中国疾病预防控制中心性病艾滋病预防控制中心党群人事办公室,北京102206 [3]云南德宏州妇幼保健院公共卫生管理科,芒市678400 [4]复旦大学公共卫生学院流行病学教研室,公共卫生安全教育部重点实验室,上海200032

出　　处：《中华疾病控制杂志》2021年第1期48-53,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家科技重大专项(2018ZX10715006-001,2018ZX10721102-004);国家重点地区艾滋病防治项目(卫办疾控发[2004]49号)。

摘　　要：目的了解云南德宏傣族景颇族自治州2016-2018年婚检人群HBV感染情况,探讨HBV感染的主要影响因素,为推动德宏州乙型肝炎(简称乙肝)防治工作的开展提供科学依据。方法对2016-2018年婚检对象的血清标本进行HBsAg检测,按照检测血清号进行配对,进行多因素Logistic线性回归分析模型分析。结果在65 639例婚检对象中,HBV感染率为3.05%(1 874/61 352);按照婚检双方是否感染HBV分为:双阴性、男阳性女阴性、男阴性女阳性和双阳性四类;结果显示,婚检双方至少一方为阳性者1 773对,占5.90%(1 773/30 068),且以男阳性女阴性为主,占3.59%(1 079/30 068)。分析四类人群构成趋势变化发现,男女均阳性者和男阴性女阳性者有所减少,男女均阴性者有所增加(均有P<0.05)。多因素分析结果显示,男阴性女阳性与双阴性对比,女性年龄≥30岁以及男性为中国籍、女性为外籍和双方均为外籍相对于均为中国籍是HBV感染的危险因素(均有P<0.05)。结论云南德宏傣族景颇族自治州婚检人群中HBV感染率有所下降,女性HBV感染可能在当地HBV传播中起到重要作用。依据所发现的HBV感染的影响因素进行科学防治,可减少HBV在婚检人群中的传播。Objective To investigate the hepatitis B virus(HBV) prevalence among the pre-marital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture from 2016 to 2018, and to explore the main factors of HBV infection. Methods Hepatitis B surface antigen was detected in serum samples of premarital medical examination subjects from 2016 to 2018. And, the main influencing factors of HBV infection were explored by multivariable Logistic liner regression model based on paired premarital subjects which were according to the serum test number. Results A total of 65 639 premarital subjects were tested, and HBV infection rate was 3.05%(1 874/61 352). Based on the HBV infection results, we divided the participants into four categories: both negative, male positive but female negative, male negative but female positive and both positive. The results showed that there were 1 773 pairs in which more than one person was positive accounted for 5.90%(1 773/30 068), and most of that was male positive but female negative, which accounted for 3.59%(1 079/30 068). According to the analysis of the composition of the four groups of people in each year, it was found the decrease in the category of both negative and in the category of male negative but female positive, and the increase in the category of both negative(P<0.05). The results of multivariate analysis showed that the risk factors were female age ≥ 30 years old, Chinese nationality of male, foreign nationality of female and foreign nationality of both sides(all P<0.05) in the male negative but female positive compared with both negative. Conclusions Detection of HBV infection in the premarital medical examination population in Dehong Dai and Jingpo Autonomous Prefecture was decreased, and HBV-positive female may play an important role in local HBV transmission. The finding of risk factors of HBV infection might be useful for reducing the spread of HBV.

关 键 词：HBV 婚检人群 影响因素 

分 类 号：R512.6+2[医药卫生—内科学]