单用功效性护肤品治疗轻中度面部玫瑰痤疮及脂溢性皮炎的多中心临床研究  

A Multicenter Clinical Study on the Treatment of Mild to Moderate Facial Rosacea and Seborrheic Dermatitis with Functional Skin Care Products Alone

作　　者：阳熙照 唐言 李吉[1] 谢红付[1] YANG Xi-zhao;TANG Yan;LI Ji(Department of Dermatology,Xiangya Hospital Central South University,Changsha Hujian 410008)

机构地区：[1]中南大学湘雅医院皮肤科,湖南长沙410008

出　　处：《医学临床研究》2021年第1期43-46,50,共5页Journal of Clinical Research

摘　　要：【目的】探讨单用功效性护肤品治疗轻中度面部玫瑰痤疮及脂溢性皮炎的临床疗效。【方法】在全国范围内17家医院皮肤科门诊招募1个月以上病史的轻中度面部玫瑰痤疮或脂溢性皮炎患者,给予面部单用功效性护肤品2周,每周复诊1次,对其临床症状(干燥、瘙痒、灼热)和体征(脱屑、红斑)进行评分,并检测其皮肤屏障指标。【结果】共324名受试者完成了试验.第1周及第2周患者的干燥、瘙痒、灼热、脱屑、红斑等症状和体征均得到了明显改善(P<0.01),治疗2周后的有效率分别为84.8%、85.3%、91.1%、78.5%、46.8%。患者面部经表皮失水(TEWL)由13.88 g/(cm^2·h)降至11.89 g/(cm^2·h);角质层含水量由62.96%升至69.88%。【结论】单用皮肤屏障修护乳可通过修复皮肤屏障功能有效治疗轻中度面部玫瑰痤疮及脂溢性皮炎,减轻患者面部皮肤的脱屑、红斑,并缓解其敏感症状,值得临床推广应用。【Objective】To investigate the clinical efficacy of single use of functional skin care products in the treatment of mild to moderate facial rosacea and seborrheic dermatitis.【Methods】Patients with mild to moderate facial rosacea or seborrheic dermatitis with a history of more than one month were recruited from dermatology clinics of 17 hospitals nationwide.They were given facial skin,care products alone for 2 weeks,and were followed up once a week.The clinical symptoms(drynessy pruritusy burning)and signs(desquamation,erythema)were scored,and their skin barrier indexes were detected.【Results】A total of 324 subjects completed the trial.The symptoms and signs of dryness,pruritus,burning,desquamation and erythema were significantly improved in the first and second weeks(P<0.01).The effective rates after two weeks of treatment were 84.8%,85.3%,91.1%,78.5% and 46.8% respectively.The TEWL decreased from 13.88 g/(cm^2·h)to 11.89 g/(cm^2·h),and the water content of stratum corneum increased from 62.96% to 69.88%.【Conclusion】Skin barrier repair milk a-lone can effectively treat mild to moderate facial rosacea and seborrheic dermatitis by repairing the skin barrier function,reduce the patients'facial skin desquamation and erythema,and relieve their sensitive symptoms,which is worthy of clinical application.

关 键 词：红斑痤疮/治疗 皮炎 脂溢性/治疗 护肤霜/治疗应用 治疗 临床研究性 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]