法舒地尔联合重组人脑利钠肽对急性心肌梗死患者PCI术后心功能及细胞凋亡因子的影响  

Effects of Fasudil Combined with Recombinant Human Brain Natriuretic Peptide on Cardiac Function and Apoptosis Factors in Patients with Acute Myocardial Infarction after PCI

作　　者：闫菊英 李烁烁 YAN Ju-ying;LI Shuo-shuo(Shandong Provincial Third Hospital,Jinan Shandong,250031,China)

机构地区：[1]山东省立第三医院,山东济南250031

出　　处：《医学临床研究》2021年第1期94-97,共4页Journal of Clinical Research

摘　　要：【目的】探讨法舒地尔联合重组人脑利钠肽对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后心功能及细胞凋亡因子的影响。【方法】回顾性分析2018年4月至2020年4月于本院行PCI术治疗的124例AMI患者的临床资料,根据治疗方法的不同将其分为观察组和对照组,每组各62例。常规治疗基础上,对照组给予法舒地尔治疗,观察组在对照组的基础上给予重组人脑利钠肽治疗。术前、术后1周,比,较两组心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、左室短轴缩短率(FS)],血清心肌损伤指标[肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、心型脂肪酸结合蛋白(H-FABP)]及细胞凋亡因子[可溶性凋亡相关因子(sFas)、可溶性肿瘤坏死因子相关性凋亡诱导配体(sTRAIL)、半胱氨酸天冬酶-3(Caspase-3)]。并比较两组患者术后3个月主要不良心血管事件(MACE)发生情况。【结果】两组患者术后1周LVEDD、LVESD水平较术前降低,且观察组低于对照组;LVEF、FS较术前提高,且观察组高于对照组,差异均有统计学意义(均P<0.05)。血清CK-MB、cTnT、H-FABP水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05)。血清sFas、sTRAIL、Caspase-3水平均低于术前,且观察组低于对照组,差异均有统计学意义(P<0.05)。术后3个月,观察组患者MACE发生率为6.45%(4/62),低于对照组的19.35%(12/62),差异有统计学意义(χ^2=4.593,P=0.032<0.05)。【结论】法舒地尔联合重组人脑利钠肽能有效改善AMI患者PCI术后心肌损伤情况,抑制心室重构及细胞凋亡,降低MACE发生风险,值得推广应用。【Objective】To investigate the effect of fasuclil combined with uretic peptide on cardiac function and apoptosis factors in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).【Methods】The clinical data of 124 patients with AMI who underwent PCI in our hospital from April 2018 to April 2020 were retrospectively analyzed.AccordinK to different treatment methods,they were divided into observation group and control group,62 cases in each group.On the basis of conventional treatment,the control group was treated with fasudiK and the observation group was treated with recombinant human brain natriuretic peptide on the basis of the control group.Before operation and one week after operation,the indexes of cardiac function(LVEDD,LVESD,LVEF,FS),serum indexes of myocardial injury(CK-MB,cTnT,H-FABP).apoptotic factors.Soluble apoptosis related factor(SFAS),soluble tumor necrosis factor rdated apoptosis inducing ligand(sTRAIL),caspase-3 were compared between the two groups.The incidence of major adverse cardiovascular events(MACE)3 months after opera tion was compared between the two groups.【Results】One week after operation,LVEDD and LVKSD levels of the two groups were lower than those before4 operation,and LVEF and FS of the observation group were high er than those of the control group,and the differences were statistically significant(mean P<0.05).Serum CK-MB,cTnT,H-FABP levels were lower than before operation,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Serum SFAS.sTRAIL and Caspase-3 levels were lower than those before operation,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Three months after operation,the incidence of mace in the observation group v/as 6.45%(4/62),which was lower than 19.35%(12/62)in the control group(χ^2=4.593,P=0.032<0.05).【Conclusion】Fasudil combined with recombinant human brain natriuretic peptide can effective

关 键 词：心肌梗死/外科学 急性病 血管成形术 气囊 冠状动脉 血管舒张药/治疗应用 利钠肽 脑/治疗应用 

分 类 号：R542.22[医药卫生—心血管疾病]