软坚散结活血行气法对肾功能不全衰竭期多囊肾患者疗效的研究  

Therapeutic Effect of of Applying Ruanjian Sanjie Huoxue Xingqi Method in the Tretment of Patients with Polycystic Kidney at the Stage of Renal Insufficiency Failure

作　　者：陈晓虎[1] 苏海燕[1] 施榧榧 李杰 CHEN Xiaohu;SU Haiyan;SHI Yuyu(Department of Emergency,Nantong Hospital of Traditional Chinese Medicine,Nantong Jiangsu 226001,China)

机构地区：[1]南通市中医院急诊科,江苏南通226001

出　　处：《四川中医》2020年第12期158-161,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察软坚散结活血行气法在治疗肾功能不全衰竭期的多囊肾(PKD)患者中的临床疗效和应用价值。方法:选取2016年9月~2018年3月本院收治肾功能不全衰竭期的PKD患者150例,随机数表法分为对照组(n=75)和观察组(n=75),对照组给予西医常规治疗,观察组在此基础上行软坚散结活血行气法治疗,连续治疗6个月后,比较两组患者的临床疗效,不同时间点的血肌酐、尿酸、肾小球滤过率、红蛋白、肾脏体积、最大囊肿直径变化和不良反应发生情况。结果:治疗后,观察组的临床疗效总有效率为98.67%高于对照组的93.33%(P<0.05);两组患者的血肌酐、尿酸、肾小球滤过率、血红蛋白、肾脏体积、最大囊肿直径均优于治疗前,且观察组的改善情况优于对照组(均P<0.05),不同指标与时间存在交互作用(均P<0.05),两组不良反应发生率无明显差异(P>0.05)。结论:软坚散结活血行气法在治疗肾功能不全衰竭期的PKD方面疗效确切,可提高治疗效果,明显改善患者的肾功能及囊肿状态,无明显不良反应,值得临床推广与应用。Objective: To investigate the clinical effect and application value of applying Ruanjian Sanjie Huoxue Xingqi Method in the treatment of patients with polycystic kidney(PKD) at the stage of renal insufficiency failure.Methods: A total of 150 patients with PKD at the stage of renal insufficiency failure who were admitted and treated in the hospital between September 2016 and March 2018 were enrolled in the study.They were randomized into controlled group and observation group by random number table method, with 75 patients in each group.The controlled group was treated with routine western medicine, and the observation group was treated by Ruanjian Sanjie Huoxue Xingqi Method based on the treatment of the controlled group.The clinical effect, changes of serum creatinine, uric acid, glomerular filtration rate, hemoglobin, renal volumeand maximum cyst diameter atdifferent time points and adverse reactions were compared between the 2 groups.Results: After treatment, the total clinical response rate of the observation group(98.67%) was higher than that of the controlled group(93.33%)(P < 0.05).Serum creatinine, uric acid, glomerular filtration rate, hemoglobin, renal volume and maximum cyst diameter in both groups were improved, and the improvement was larger in the observation group than in the controlled group(P < 0.05).There were interactions between different indexes and time(P < 0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P > 0.05).Conclusion: Ruanjian Sanjie Huoxue Xingqi Method is effective in the treatment of patients with PKD at the stage of renal insufficiency failure.It can improve the curative effect and significantly improve the patient’s renal function and status of thecyst, without obvious adverse reactions.

关 键 词：多囊肾 肾功能不全 血肌酐 

分 类 号：R692.5[医药卫生—泌尿科学]