Research progress on biodosimeters of ionizing radiation damage  

作　　者：Changyan Xiao Ningning He Yang Liu Yan Wang Qiang Liu 

机构地区：[1]Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300192,China

出　　处：《Radiation Medicine and Protection》2020年第3期127-132,共6页放射医学与防护（英文）

基　　金：This review was funded by Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2017-1001-08);National Natural Science Foundation of China(81772243,31971168,81803172).

摘　　要：Ionizing radiation can cause radiation injury to the human body under certain circumstances,such as unexpected radiation accidents and nuclear terrorist attacks.Methods that can accurately and rapidly measure the biological effects are necessary for rational triage and treatment of affected patients.In recent decades,significant researches attention has been focused on the development of accurate and efficient biodosimeters.In this review,we summarize recent developments in biological dosimeters,with a primary focus on cell-based and molecular markers,including comet assay,dicentric chromosome aberration,γ-H2AX,micronuclei,microRNA,lncRNA,and 8-Oxo-dG.

关 键 词：Ionizing radiation Radiation injury Biodosimeter Comet assay Dicentric chromosome aberration Γ-H2AX Micronuclei MICRORNA lncRNA 8-Oxo-dG 

分 类 号：R81[医药卫生—放射医学]