中医药在肾间质纤维化中自噬相关机制研究进展  

Research Progress of Autophagy-Related TCM Mechanisms in Renal Interstitial Fibrosis

作　　者：罗珊 宋立群[1] 代丽娟[1] 盛紫阳 于珊珊[2] 楚鎏慈 贠捷[1] LUO Shan;SONG Liqun;DAI Lijuan;SHENG Ziyang;YU Shanshan;CHU Liuci;YUN Jie(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学第一附属医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2021年第2期98-103,共6页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金青年基金项目(81804088)。

摘　　要：自噬是细胞内普遍存在的新陈代谢过程,能够保持内部环境稳定。研究表明,自噬可参与肾间质纤维化进程中的诸多环节,但在这个过程中有时会出现相互矛盾的结果,即自噬可以改善肾间质纤维化,但过度自噬反而会加重纤维化。自噬所表现出的双向调节作用与中医学之阴阳理论、气虚痰瘀理论在一定程度上是相符合的。因此,通过中医药调控细胞自噬可能是防治肾间质纤维化新的作用靶点。本文将以此为切入点作一综述,旨在为今后肾间质纤维化的临床治疗及新药研发提供参考依据。Autophagy is a ubiquitous metabolic process in cells that can keep the internal environment stable.Studies have shown that autophagy can participate in many links in the process of renal interstitial fibrosis,but sometimes there are conflicting results in this process,that is,autophagy can improve renal interstitial fibrosis,but excessive autophagy will increase the fiber.To a certain extent,the two-way regulation effect of autophagy is consistent with the TCM theory of yin and yang and the TCM theory of qi deficiency and phlegm stagnation.Therefore,the TCM regulation of autophagy may be a new target for prevention and treatment of renal interstitial fibrosis.This study took this as an entry point for a review,aiming to provide a reference for future clinical treatment and new drug development of renal interstitial fibrosis.

关 键 词：肾间质纤维化 自噬 中医药 

分 类 号：R2-03[医药卫生—中医学]