加味芪榔方治疗气阴两虚型药物依赖性便秘临床研究  

Clinical Study on Modified Qilang Prescription in Treating Drug-dependent Constipation of Deficiency of Qi and Yin

作　　者：周蒙恩 晏旎 陈懿榕 林柳兵[2] 李勇[2] ZHOU Mengen;YAN Ni;CHENG Yirong(2018 postgraduate student of Shanghai University of Traditional Chinese Medicine,Shanghai 201203;不详)

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学附属市中医医院脾胃病科,上海200071

出　　处：《河北中医》2020年第12期1791-1796,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：上海市科学技术委员会科研计划项目(编号:18401904000)。

摘　　要：目的观察加味芪榔方治疗气阴两虚型药物依赖性便秘的临床疗效。方法将74例气阴两虚型药物依赖性便秘患者按照随机数字表法分为治疗组和对照组,各37例。治疗组35例(剔除2例)予加味芪榔方+乳果糖口服液模拟剂治疗,对照组37例予加味芪榔方模拟剂+乳果糖口服液治疗。均治疗8周,比较2组治疗前后便秘症状评分(包括粪便性状、排便费力、排便时间、下坠不尽胀感、排便频率及腹胀)、中医症状评分(包括排便次数、大便干结、排便无力、纳呆、腹胀、乏力、排便不尽及心烦少寐)、便秘患者症状自评问卷(PAC-SYM)评分及便秘患者生活质量自评问卷(PAC-QOL)评分(包括生理功能、社会心理、担忧度及满意度)变化情况,2组均治疗结束4周后对临床痊愈、显效、有效的患者进行随访并比较疾病复发率情况。结果治疗组总有效率94.29%(33/35),复发率18.18%(6/33),对照组总有效率81.08%(30/37),复发率53.33%(16/30),治疗组总有效率高于对照组(P<0.05),复发率低于对照组(P<0.05)。2组治疗后各项便秘症状评分及总积分较治疗前均明显降低(P<0.05),治疗组治疗后除下坠不尽胀感评分外,其余各项评分及总积分均低于对照组(P<0.05)。2组治疗后各项中医症状评分及总积分较治疗前均明显降低(P<0.05),治疗组治疗后除排便不尽评分外,其余各项评分及总积分均低于对照组(P<0.05)。2组治疗后PAC-SYM评分较治疗前均明显降低(P<0.05),治疗组治疗后PAC-SYM评分低于对照组(P<0.05)。2组治疗后PAC-QOL各方面评分较治疗前均明显降低(P<0.05),治疗组治疗后PAC-QOL各项评分均低于对照组。结论加味芪榔方治疗气阴两虚型药物依赖性便秘临床疗效确切,可有效改善患者便秘症状,改善中医症状,提高生活质量,提高临床疗效,且复发率低。Objective To observe the clinical efficacy and safety of Jiawei Qilang prescription in the treatment of drug-dependent constipation(Qi-Yin Deficiency Type).Methods Seventy four patients with drug-dependent constipation of qi and yin deficiency type were randomly divided into treatment group and control group,37 cases in each group.Thirty five cases(excluding 2 cases)in the treatment group were treated with Jiawei Qilang Formula and simulant of oral lactulose liquid,while 37 cases in the control group were treated with the simulant of Jiawei Qilang Formula and oral lactulose liquid.Both groups were treated for 8 weeks,and the changes of constipation symptom score(Including stool character,defecation effort,defecation time,falling feeling,defecation frequency and abdominal distention),TCM syndrome score(Including the number of defecation,dry stools,weak defecation,anorexia,abdominal distension,fatigue,endless defecation and sleeplessness),constipation patients symptom self-assessment questionnaire(PAC-SYM)score and constipation patients'quality of life self-assessment questionnaire(PAC-QOL)score(including physiological function,social psychology,anxiety and satisfaction)before and after treatment were compared between the two groups.After 4 weeks of treatment,the patients with clinical recovery,significant effect and certain effect were followed up and the recurrence rate of the disease was compared between the two groups.Results The total effective rate and recurrence rate in the treatment group were 18.18%(6/33)and 94.29%(33/35),while the control group was 81.08%(30/37)and 53.33%(16/30).The treatment group always had higher efficacy than the control group(P<0.05),and the recurrence rate was lower than the control group(P<0.05).The constipation symptom scores and total scores of the two groups after treatment were significantly lower than those before treatment(P<0.05).Except the score of falling of endless bloating,the other scores and total scores of the treatment group after treatment were lower than those of t

关 键 词：便秘 气阴两虚 中药疗法 

分 类 号：R256.35[医药卫生—中医内科学]