安宫牛黄丸联合常规治疗对急性脑梗死恢复期患者的临床疗效  

Clinical effects of Angong Niuhuang Pills combined with conventional treatment on patients with acute cerebral infarction in recovery period

作　　者：郑芳昆 龙登毅 贝筝 于航 ZHENG Fang-kun;LONG Deng-yi;BEI Zheng;YU Hang(Department of Neurology,Hainan Provincial Cadre Sanatorium(Hainan Provincial Geriatric Hospital),Haikou 571100,China;Department of Critical Care Medicine,The Second Hospital Affiliated to Hainan Medical College,Haikou 570000,China)

机构地区：[1]海南省干部疗养院(海南省老年病医院)神经内科,海南海口571100 [2]海南医学院第二附属医院重症医学科,海南海口570000

出　　处：《中成药》2021年第2期381-384,共4页Chinese Traditional Patent Medicine

摘　　要：目的探讨安宫牛黄丸联合常规治疗对急性脑梗死恢复期患者的临床疗效。方法100例患者随机分为对照组和观察组,每组50例,对照组给予常规治疗(阿司匹林、阿托伐他汀、康复运动训练),观察组在对照组基础上加用安宫牛黄丸,疗程14 d。检测临床疗效、Fugl⁃Meyer评分、NIHSS评分、血流量指标(Vm、PI)、血管内皮细胞因子(NO、ET⁃1、AngⅡ)、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组Fugl⁃Meyer评分、Vm、NO升高(P<0.05),NIHSS评分、PI、ET⁃1、AngⅡ降低(P<0.05),以观察组更明显(P<0.05)。2组均无明显不良反应。结论安宫牛黄丸联合常规治疗可改善急性脑梗死恢复期患者肢体功能、脑血流灌注量,其机制可能与改善血管内皮功能有关。AIM To explore the clinical effects of Angong Niuhuang Pills combined with conventional treatment on patients with acute cerebral infarction in recovery period.METHODS One hundred patients were randomly assigned into control group(50 cases)for 14⁃day intervention of conventional treatment(aspirin,atorvastatin,therapeutic exercise training),and observation group(50 cases)for 14⁃day intervention of both Angong Niuhuang Pills and conventional treatment.The changes in clinical efficacy,Fugl⁃Meyer score,NIHSS score,blood flow volume indices(Vm,PI),vascular endothelial cytokines(NO,ET⁃1,AngⅡ)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed increased Fugl⁃Meyer score,Vm and NO(P<0.05),and decreased NIHSS score,PI,ET⁃1 and AngⅡ(P<0.05),especially for the observation group(P<0.05).No obvious adverse reactions were found in the two groups.CONCLUSION For the patients with acute cerebral infarction in recovery period,Angong Niuhuang Pills combined with conventional treatment can improve limb functions and cerebral blood flow perfusion,whose mechanism may contribute to the improvement of vascular endothelial functions.

关 键 词：安宫牛黄丸 常规治疗 急性脑梗死 恢复期 

分 类 号：R287[医药卫生—中药学]