衢州市2006—2010年出生儿童流行性腮腺炎发病及疫苗接种情况分析  

Analysis on incidence and vaccination of mumps among children born from 2006 to 2010 in Quzhou City

作　　者：尹志英[1] 龚晓英[1] 来时明 王双青[1] 方春福[1] 方泉均 李俊姬 YIN Zhi-ying;GONG Xiao-ying;LAI Shi-ming;WANG Shuang-qing;FANG Chun-fu;FANG Quan-jun;LI Jun-ji(Quzhou Municipal Center for Disease Control and Prevention,Quzhou,Zhejiang 324000,China)

机构地区：[1]衢州市疾病预防控制中心,浙江衢州324000

出　　处：《中国公共卫生管理》2020年第6期824-827,共4页Chinese Journal of Public Health Management

基　　金：衢州市科技局项目(20172090);浙江省预防医学会免疫规划软课题(2017YF03)。

摘　　要：目的通过分析衢州市2006-2010年出生儿童流行性腮腺炎(流腮)发病及疫苗接种情况,探讨疫苗接种率和接种间隔对流腮发病的影响。方法分别从"疾病监测信息报告管理系统"和"浙江省免疫规划信息系统"中导出衢州市2006-2010年出生儿童流腮个案和疫苗接种数据,采用Excel 2007和SPSS 17.0软件对所有数据进行整理和分析。结果衢州市2006-2010年出生儿童累计报告流腮临床诊断病例921例,其中0、1、2剂次含流腮成分疫苗(MuCV)免疫史病例构成比分别为7.60%、38.65%、53.75%,发病高峰年龄分别为2岁以内、2~5岁和5岁以后。各出生队列的报告发病率在985.90/10万(2006年出生)~479.51/10万(2010年出生)之间(χ趋势^2=63.940,P<0.01),以柯城区发病数最多,6月份为发病高峰,男女性别发病数比值波动在1.56(2007年出生)~2.26(2009年出生),1剂麻腮风联合减毒活疫苗(MMR)累计接种率在91.57%(2006年出生)~98.89%(2010年出生)之间,发病高峰年龄由3~4岁(2006年出生)后移至5~6岁(2010年出生)。结论衢州市适龄儿童1剂MMR的接种率较高,接种第2剂MuCV是对第1剂MMR流腮抗体的补充,建议引入2剂MMR常规免疫程序,接种间隔4年左右。Objective To analyze the incidence and vaccination of mumps among children born from 2006 to 2010 in Quzhou City,and to explore the influence of vaccination rate and vaccination interval on the incidence of mumps.Methods The mumps cases and vaccination data of children born from 2006 to 2010 in Quzhou City were obtained from the National Notifiable Disease Reporting System and the Zhejiang Provincial Immunization Information System,respectively,and all the data were sorted out and analyzed by Excel 2007 and SPSS17.0 software.Results A total of 921 mumps cases were reported among children born from 2006 to 2010 in Quzhou City,and the constituent ratio of mumps cases without mumps containing vaccine(MuCV)Immunization,with one-doses MuCV Immunization and with two-doses MuCV Immunization was 7.60%,38.65%and 53.75%,respectively.The peak age of onset was under 2 years old,2-5 years old and after 5 years old,respectively.The reported incidence rate of each birth cohort was between 985.90/100000(born in 2006)and 479.51/100000(born in 2010)(χ~2=63.940,P<0.01),most number of cases were in Kecheng District,June was the peak season,the ratio of male to female ranged from 1.56(born in 2007)to 2.26(born in 2009).The cumulative vaccination rate of one-dose measles,mumps and rubella combined attenuated live vaccine(MMR)ranged from 91.57%(born in 2006)to 98.89%(born in 2010),the peak age of the incidence shifted from 3-4 years old(born in 2006)to 5-6 years old(born in 2010).Conclusion The vaccination rate of one-dose MMR among children aged 1.5-2 years is high in Quzhou,the second dose MuCV is a supplement of mumps antibody to the first dose MMR.It is suggested to introduce two doses MMR routine immunization procedure,with the vaccination interval is about 4 years.

关 键 词：流行性腮腺炎 疫苗 接种率 接种间隔 

分 类 号：R512.1[医药卫生—内科学] R181.3[医药卫生—临床医学]