北京市延庆区2017年健康人群麻疹抗体水平分析  

Analysis of measles antibody level in healthy population in Yanqing District of Beijing in 2017

作　　者：狄飞 张曙光 武书彦 张英英 刘书平 娄畅 DI Fei;ZHANG Shu-guang;WU Shu-yan;ZHANG Ying-ying;LIU Shu-ping;LOU Chang(Yanqing District Center for Disease Control and Prevention,Beijing 102100,China)

机构地区：[1]北京市延庆区疾病预防控制中心,北京102100

出　　处：《中国公共卫生管理》2020年第6期874-876,共3页Chinese Journal of Public Health Management

摘　　要：目的掌握人群麻疹抗体水平分布,为制定消除麻疹策略提供科学依据。方法 2017年2-7月随机抽取延庆区10个村共250名健康人群,分10个年龄组。采用问卷调查的方法调查人口学特征、麻疹免疫史、患病史等,并采集静脉血监测麻疹IgG抗体。比较抗体阳性率和抗体滴度水平。结果总阳性率75.20%,总抗体水平中位数678.35IU/L。男性和女性、城市和农村、平原山区和半山区、本市和外省户籍人群麻疹抗体阳性率和抗体水平中位数差异无统计学意义(P>0.05)。有麻疹疫苗者抗体阳性率和抗体水平中位数分别为87.23%和895.39IU/L,均高于既往无麻疹疫苗免疫史者的67.95%和547.48IU/L,差异有统计学意义(P<0.05)。不同年龄组抗体阳性率和抗体水平中位数差异有统计学意义(P<0.05)。其中,<1岁婴幼儿最低,1~4岁、5~9岁、≥40岁人群较高。结论 1~9岁和≥40岁人群抗体阳性率和抗体水平较高,发病风险较低;<1岁尤其是0~7月人群抗体阳性率和抗体水平较低,发病风险较高。延庆区总体抗体水平偏低,有待提高。Objective To master the distribution of measles antibody level among the population,and to provide scientific basis for formulating the strategies of eliminating measles.Methods From February to July 2017,a total of 250 healthy people were randomly selected from 10 villages in Yanqing District,and they were divided into 10 age groups.Demographic characteristics,measles immune history,disease history and so on were investigated by questionnaire survey,and venous blood was collected,and measles IgG antibody was monitored.The antibody positive rates were compared,and the antibody titer levels were compared.Results The total positive rate of 250 persons was 75.20%,and the median antibody level was 678.35 IU/L.There were no statistically significant differences in measles andtibody positive rate and median measles antibody level between male and female,urban and rural,plain and mid-levels,registered people in the city and other provinces(P>0.05).The antibody positive rate and median antibody level of the patients with measles vaccine was 87.23%and 895.39 IU/L,respectively,which were higher than that of the patients without previous history of measles vaccine immunization(67.95%and 547.48 IU/L),and the differences were statistically significant(P<0.05).The differences of antibody positive rate and median antibody level in different age groups were statistically significant(P<0.05).Among them,the age group of infants under 1 year old was the lowest,and the age group of 1-4 years old,5-9 years old and above 40 years old had higher rate.Conclusion The antibody positive rate and antibody level of people aged 1-9 years and over 40 years old are higher,and the risk of disease is lower;the antibody positive rate and antibody level are lower in the age group of less than 1 year old,especially 0-7 months,and the incidence risk is higher.The overall antibody level in Yanqing District is low and needs to be improved.

关 键 词：麻疹抗体 阳性率 免疫屏障 消除麻疹 

分 类 号：R181.3[医药卫生—流行病学]