注射用阿昔洛韦与多种药物配伍稳定性的文献分析  

Literature analysis on the compatibility stability of acyclovir for injection with several drugs

作　　者：张雪花 李艳娇[1] 宋燕青[1] 高欢 ZHANG Xuehua;LI Yanjiao;SONG Yanqing;GAO Huan(Department of Pharmacy,The First Hospital of Jilin University,Changchun,Jilin 130021,China)

机构地区：[1]吉林大学第一医院药学部,吉林长春130021

出　　处：《安徽医药》2021年第2期417-421,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金青年科学基金项目(81903712);吉林大学第一医院青年发展基金(JDYY92018014)。

摘　　要：目的总结注射用阿昔洛韦与临床常用药物的配伍安全性,为临床合理使用药物提供参考。方法通过数据库(知网、万方、维普等)查找2009年1月至2019年7月临床上与注射用阿昔洛韦存在配伍变化的常用药物,并进行统计分析。结果注射用阿昔洛韦与0.9%氯化钠注射液可稳定配伍;不宜与5%葡萄糖注射液、5%葡萄糖氯化钠注射液、10%葡萄糖注射液、5%转化糖注射液、10%果糖注射液、注射用头孢硫脒、注射用盐酸多柔比星、热毒宁注射液、银杏达莫注射液、盐酸溴己新注射液、注射用盐酸氨溴索、注射用阿莫西林克拉维酸钾、头孢哌酮钠他唑巴坦钠、长春西汀注射液、盐酸昂丹司琼注射液、注射用氨曲南、盐酸赖氨酸、果糖二磷酸钠、注射用灯盏花素、注射用双黄连、注射用丹参多酚酸盐、盐酸左氧氟沙星注射液、注射用维生素C、复方氨基酸、注射用盐酸头孢甲肟、注射用单磷酸阿糖腺苷、多巴胺、盐酸吡硫醇配伍使用。结论注射用阿昔洛韦与多种药物存在配伍变化,临床中应尽量避免与以上药物联合应用,以保证病人用药安全性。Objective To summarize the compatibility safety of acyclovir for injection with commonly used drugs in clinic,and to provide reference for rational drug selection in clinic.Methods Data bases(CNKI,Wanfang,Vip,etc.)were used to search for commonly used drugs that had compatibility changes with acyclovir for injection during January 2008-July 2019,and statistical analysis was made.Results Acyclovir for injection and 0.9%sodium chloride injection can be compatible stably;It should not be compatible with 5%glucose injection,5%glucose sodium chloride injection,10%glucose injection,5%converted sugar injection,10%fructose injection,cefathiamidine for injection,doxorubicin hydrochloride for injection,reduning injection,ginkgo biloba-damo injection,bromhexine hydrochloride injection,ambroxol hydrochloride for injection,amoxicillin clavulanate potassium for injection,cefoperazone sodium tazobactam sodium,vinpocetine injection,ondansetron hydrochloride injection,aztreonam for injection,lysine hydrochloride,fructose sodium diphosphate,breviscapine for injection,shuanghuanglian for injection,Salvia miltiorrhiza polyphenolates for injection,levofloxacin hydrochloride injection,vitamin C for injection,compound amino acid,cefmethime hydrochloride for injection,adenosine monophosphate dopamine,pyrithiol hydrochloride for injection,dopamine andpyrithiol hydrochloride.Conclusion Acyclovir for injection is compatible with many drugs,so it should be avoided to use it in combination with the above drugs in order to ensure the safety of patients.

关 键 词：阿昔洛韦 药物配伍禁忌 用药安全 合理用药 

分 类 号：R942[医药卫生—药剂学]