连续捐献单采血小板献血者血红蛋白和铁蛋白状况调查及分析  

Hemoglobin and ferritin status in frequent plateletpheresis donors

作　　者：王瑞[1] 葛红卫[1] 郭瑾[1] 贾俊杰[1] 施欣[1] 王鸿捷[1] WANG Rui;GE Hongwei;GUO Jin;JIA Junjie;SHI Xin;WANG Hongjie(Beijing Red Cross Blood Center,Beijing 100088,China)

机构地区：[1]北京市红十字血液中心,北京100088

出　　处：《中国输血杂志》2021年第1期12-15,共4页Chinese Journal of Blood Transfusion

摘　　要：目的调查连续捐献单采血小板对献血者血红蛋白和铁蛋白的影响。方法选择2018年3~6月北京市红十字血液中心男性献血者73名(平均献血周期为15.26 d),依据5次献血的铁蛋白水平分为第1组(n=21,≥30μg/L)、第2组(n=23,<30μg/L)和第3组(n=29,在30μg/L上下变化),对其连续捐献5次单采血小板时的血红蛋白、铁蛋白进行检测并做对比分析。结果 1)73名献血者连续5次献血对应的血红蛋白浓度无统计学差异(P>0.05),铁蛋白浓度呈下降趋势(P<0.01),铁蛋白低值率随献血次序递增而增高(35.62%~63.01%)。2)第1组和第2组献血者连续5次献血血红蛋白浓度无统计学差异、铁蛋白浓度呈下降趋势。除第4次外,第1组血红蛋白浓度均高于第2组、差异有统计学意义。3)将血红蛋白献血阈值从120 g/L提升至135 g/L可将献血者铁蛋白低值率从23.23%降低为18.00%,但血液资源减少10.61%。结论单采血小板献血者随着献血次数增加铁储存下降,血红蛋白在降低献血者铁缺乏风险的功效不佳,对频繁献血者开展铁蛋白检测非常必要。Objective To investigate and analyze the effect of frequent platelet donation on hemoglobin(Hb) and ferritin in blood donors. Methods 73 male plateletpheresis donors, with an average donation interval of 15.26 days, in Beijing Red Cross Blood Center between March 2019 to June 2019 were enrolled into this study. These donors were classified into 3 groups according to the ferritin level during the 5 consecutive donations: 1st group(n=21, ferritin ≥30 μg/L), 2nd group(n=23, ferritin<30 μg/L) and 3rd group(n=29, ferritin fluctuated at 30 μg/L). Their Hb and ferritin during the 5 consecutive donation were detected and further analyzed.Results 1) No significant difference was found in Hb during the 5 consecutive donations(P>0.05), and the ferritin decreased gradually(P<0.01). The incidence of low-value ferritin increased with the donations(35.62%-63.01%). 2) The same change trend in Hb and ferritin was observed in 1st and 2nd group, except for Hb at 4th donation was significantly higher in 1st group than it in 2nd group. 3) Increasing Hb threshold for donation from 120 g/L to 135 g/L can reduce the incidence of low-value ferritin from 23.23% to 18.00%, but also lead to a decrease of blood resources by 10.61%.Conclusion A progressive decline in iron reserve was observed in frequent platepheresis donors, with minimal impact of Hb on reducing the risk of iron deficiency. It is particularly necessary to carry out ferritin testing for frequent platepheresis donors.

关 键 词：单采血小板献血者 血红蛋白 铁蛋白 铁蛋白低值率 

分 类 号：R591.1[医药卫生—内科学] R446.11[医药卫生—诊断学]