血小板抗体与不良妊娠及妊娠次数的关联性分析  

Correlation analysis of platelet antibody between adverse pregnancy and the number of pregnancies

作　　者：王九菊 张丽洁[2] 赵舒祺[2] 魏绪仓 李文生[1,2] WANG Jiuju;ZAHNG Lijie;ZHAO Shuqi;WEI Xucang;LI Wensheng(Department of Pathology,Xi'an Jiaotong University Health Science Center,Xi'an 710049,China;Shaanxi Provincial People's Hospital)

机构地区：[1]西安交通大学医学部基础医学院,陕西西安710049 [2]陕西省人民医院

出　　处：《中国输血杂志》2021年第1期32-34,共3页Chinese Journal of Blood Transfusion

摘　　要：目的分析266例孕妇外周血血小板抗体检测结果,探讨血小板抗体与不良妊娠及妊娠次数的关系。方法选取陕西省人民医院266例孕妇,进行血小板抗体检测,根据有无不良妊娠分为2组,比较其血小板抗体阳性率;同时,根据妊娠次数分为A组(1次)、B组(2次)、C组(≥3次),比较其血小板抗体阳性率。结果有不良妊娠组与无不良妊娠组血小板抗体阳性率(31.81%vs 14.86%)比较差异有统计学意义(P<0.05),妊娠次数不同的3组间血小板抗体阳性率(A组:9.09%;B组:21.62%;C组:23.65%)比较差异有统计学意义(P<0.05),组间的趋势χ2检验统计学分析显示,妊娠次数和血小板抗体有线性趋势(P<0.05)。结论血小板抗体与不良妊娠有关,有不良妊娠组血小板抗体阳性率高于无不良妊娠组;血小板抗体与妊娠次数有线性趋势,妊娠次数越多,抗体阳性率越高。将血小板抗体检测作为妊娠期常规检测项目,有利于临床对不良妊娠孕妇的早发现,以及对胎儿/新生儿同族免疫性血小板减少性紫癜等疾病的早预防、早发现、早干预。Objective To analyze the testing results of platelet antibody in peripheral blood of 266 pregnant women, so as to explore the correlation of platelet antibody between adverse pregnancy and the number of pregnancies. Methods A total of 266 pregnant women, admitted to Shaanxi Provincial People′s Hospital, were selected for platelet antibody detection. They were divided into two groups according to history of adverse pregnancy, and the positive rate of platelet antibody between two groups was compared. They were divided into group A(1 pregnancy), group B(2 pregnancies) and group C(≥3 pregnancies) in parallel, and the positive rate of platelet antibody among three groups was compared Results The yield rate of platelet antibody in groups with and without adverse pregnancy was 31.81% vs 14.86%, showing statistical significance(P<0.05). The yield rate of platelet antibody of Group A, B and C was 9.09%, 21.62% and 23.65%,respectively,with The significant differences(P<0.05). The statistical analysis of inter-group χ~2 test demonstrated a linear trend between the number of pregnancies and platelet antibodies yielding(χ~2=7.056, P<0.05). Conclusion Platelet antibody was correlated with adverse pregnancy, and the yield rate of platelet antibody in the group with adverse pregnancy was higher than that in the group without adverse pregnancy. There was a linear trend between platelet antibodies yielding and the number of pregnancies. The yield rate of antibodies gets higher as the number of pregnancies increased. Taking platelet antibody test as a routine test during pregnancy is conducive to the early detection of clinical adverse pregnancy, as well as the early prevention, early detection and early intervention of fetal/neonatal homoimmune thrombocytopenic purpura and other diseases.

关 键 词：血小板抗体 不良妊娠 妊娠次数 

分 类 号：R333.143[医药卫生—人体生理学] R271.41[医药卫生—基础医学]