陕西地区无偿献血者Wra抗原分布多态性及其抗体频率调查——附临床抗-Wra鉴定2例  

Antigen profile and antibody frequency of Wr~a in voluntary blood donors in Shaanxi province, containing 2 clinical cases of anti-Wr~a identification

作　　者：褚晓月 左琴琴[1] 毛娟[1] 吴大洲[1] 张薇薇 王红[1] 张良子 徐华[1] CHU Xiaoyue;ZUO Qinqin;MAO Juan;WU Dazhou;ZHANG Weiwei;WANG Hong;ZHANG Liangzi;XU Hua(不详)

机构地区：[1]陕西省血液中心,陕西西安710061

出　　处：《中国输血杂志》2021年第1期52-54,共3页Chinese Journal of Blood Transfusion

基　　金：2020年西安市科技计划项目(20YXYJ0009-6);西安市卫生健康委员会科研项目(2020yb47)。

摘　　要：目的对陕西地区无偿献血者中Wra抗原频率及抗-Wra频率进行筛查。方法使用血清学试验进行Wra抗原及抗-Wra频率的筛查以及血型、抗体鉴定;使用基因检测方法进行确认。结果筛查得出陕西地区7 490名无偿献血者中Wra抗原检出率为0.013%(1/7 490);729名无偿献血者中抗-Wra的检出频率为0.823%(6/729)。结论本研究对Wra抗原及其抗体的多态性进行研究,了解其在人群中的分布规律,对评估输血风险,以及相关抗体的筛查和鉴定具有指导意义。Objective To understand the antigen profile and antibody frequency of Wr~a in voluntary blood donors in Shaanxi province. Methods Wr~a antigen and antibody screening as well as blood group typing and antibody identification were performed by serological tests and confirmed by genetic testing. Results The incidence of Wr~a antigen in 7 490 voluntary blood donors was 0.013%(1/7 490),and the frequency of anti-Wr~a in 729 voluntary blood donors was 0.823%(6/729).Conclusion This study explored the polymorphism of Wr~a antigen and antibodies in blood donors,which is informative in the risk assessment of blood transfusion and the screening and identification of respective antibodies.

关 键 词：抗-Wra Wra抗原 基因分型 抗原多态性 

分 类 号：R457.11[医药卫生—治疗学]