柳州地区合格献血者戊型肝炎感染情况调查  

Hepatitis E virus seroprevalence among blood donors in Liuzhou, China

作　　者：刘峭梅[1] 王荔[1] 伍圣克 张素芳[1] 唐余茂 覃柳燕[1] 刘艳琼[1] 孙雪芬[1] 李雄英[1] LIU Qiaomei;WANG Li;WU Shengke;ZHANG Sufang;TANG Yumao;QIN Liuyan;LIU Yanqiong;SUN Xuefen;LI Xiongying(Guangxi Blood Center,Liuzhou 545005,China)

机构地区：[1]广西壮族自治区血液中心,广西柳州545005

出　　处：《中国输血杂志》2021年第1期62-64,共3页Chinese Journal of Blood Transfusion

基　　金：广西卫生健康委科研课题项目(Z20190328)。

摘　　要：目的调查柳州地区无偿献血者戊型肝炎病毒感染情况。方法对2019年10~11月柳州地区合格献血者血液标本进行ELISA法戊肝病毒抗原(HEV-Ag)、抗体(HEV-IgG和HEV-IgM)检测;对HEV-Ag阳性和(或)HEV-IgM阳性者进行HEV RNA检测;对各检测结果进行统计分析。结果本次检测5 751人份合格献血者标本,其中:HEV-Ag阳性0人份;HEV-IgG阳性1 497人份,阳性率26.03%;HEV-IgM阳性96人份,阳性率1.67%;送检91人份HEV-IgM阳性标本中均未检出HEV RNA。HEV-IgM阳性标本中有60.41%合并HEV-IgG阳性。HEV感染率,在不同性别、不同年龄、不同民族间均有差异(P<0.05)。结论本地区献血者的HEV IgG、HEV-IgM感染率高于全国其他地区,45岁以上年龄段感染率最高,苗族、侗族等少数民族感染率高于汉族。为确保输血安全,可扩大筛查数量,对输血后戊型肝炎感染的潜在风险进行全面评估,有必要时可针对高危感染人群增加HEV感染标志物检测项目。Objective To investigate the hepatitis E virus(HEV) infection among voluntary blood donors in Liuzhou, Guangxi.Methods Qualified blood donations in Liuzhou from October to November 2019 were tested for anti-HEV IgG and IgM and.HEV antigen. HEV RNA test was performed on samples positive for HEV antigen and/or anti-HEV IgM. and the test results were analyzed statistically.Results The seroprevalence rates of HEV antigen and anti-HEV IgG and IgM among 5 751 qualified donations were 0, 26.03%(1497/5 751), and 1.67%(96/5 751), respectively.None of the 91 anti-HEV IgM positive samples was positive for HEV RNA, whereas 60.41% of anti-HEV IgM positive samples were anti-HEV IgG positive. The HEV antibody prevalence varied significantly by gender, age, and nationality(P<0.05). Conclusion The prevalence of anti-HEV IgG/IgM among blood donors in Liuzhou was higher than that in other domestic regions. Significant increase in HEV antibody prevalence was observed among ethnic minorities, such as Miao and Dong, and age group of more than 45 years.Follow-up studies with larger sample size could be conducted to estimate potential risks of HEV transmission by blood transfusion, which may provide references for selective screening of HEV infection marker among high-endemic population.

关 键 词：献血者 戊型肝炎 戊肝病毒 HEV-IgG/IgM HEV-Ag 

分 类 号：R457.1[医药卫生—治疗学] R373.2[医药卫生—临床医学]