Rubidium-modified bioactive glass-ceramics with hydroxyapatite crystals for bone regeneration  

用于骨再生的铷改性生物活性玻璃陶瓷

作　　者：Yan-ni TAN Wen-juan CHEN Wei WEI Qian-li HUANG Xiang HE 谭彦妮;陈文娟;韦伟;黄千里;和祥(中南大学粉末冶金国家重点实验室,长沙410083)

机构地区：[1]State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China

出　　处：《Transactions of Nonferrous Metals Society of China》2021年第2期521-532,共12页中国有色金属学报（英文版）

基　　金：The authors are grateful for the financial supports from the Natural Science Foundation of Hunan Province,China(2019JJ50797);the Postdoctoral Science Foundation of China(2019T120711).

摘　　要：In order to study the influence of rubidium(Rb)addition on the phase composition,microstructure,mechanical properties and cell response of bioactive glass-ceramics,CaO−SiO2−Na2O−B2O3−MgO−ZnO−P2O5 glass system was designed with and without addition of Rb.The results show that hydroxyapatite(HA)and Mg−whitelockite(Ca18Mg2H2(PO4)14)crystalline phases are formed in the glass matrix without Rb.After the addition of Rb,only HA phase is detected.The grain size of the crystals in the glass-ceramics is larger with the addition of Rb than that of samples without Rb.Rb addition can improve the bending strength of glass-ceramics.The cultivation of human bone marrow mesenchymal stem cells(hBMSCs)on Rb-containing glass-ceramics demonstrates enhanced cell adhesion,proliferation and ALP activity.In conclusion,Rb-modified glass-ceramics exhibit good mechanical property,excellent bioactivity and biocompatibility,which have potential for bone regeneration application.为了研究铷(Rb)元素对CaO−SiO2−Na2O−B2O3−MgO−ZnO−P2O5系生物玻璃陶瓷的相组成、显微结构、力学性能和细胞响应的影响,设计加铷和不加铷的玻璃陶瓷成分。结果表明,在不含Rb的生物玻璃陶瓷基体中形成羟基磷灰石(HA)和Mg−白磷钙矿(Ca18Mg2H2(PO4)14)晶相;而添加Rb后,仅检测到HA相。添加Rb后,生物玻璃陶瓷中晶体的晶粒尺寸增大。添加Rb可以提高生物玻璃陶瓷的抗弯强度。细胞实验结果显示,含Rb的生物玻璃陶瓷具有更好的细胞粘附、增殖和碱性磷酸酶(ALP)活性。总之,含Rb玻璃陶瓷具有良好的力学性能、优良的生物活性和生物相容性,有望应用于骨再生领域。

关 键 词：CaO−SiO2−Na2O−B2O3−MgO−ZnO−P2O5 RUBIDIUM bioactive glass-ceramics HYDROXYAPATITE human bone mesenchymal stem cells 

分 类 号：TQ171.733[化学工程—玻璃工业] R318.08[化学工程—硅酸盐工业]