炎症指标和颈动脉硬化狭窄的相关性研究  

Relevance Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Carotid Stenosis

作　　者：胡佳阳 张亮 马涛 常清文 段顺 杨植[1] HU Jia-yang;ZHANG Liang;MA Tao;CHANG Qian-wen;DUAN Shun;YANG Zhi(Affiliated Hospital of Chengde Medical College,Chengde Hebei,067000,China)

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《承德医学院学报》2021年第1期23-27,共5页Journal of Chengde Medical University

摘　　要：目的探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和颈动脉狭窄程度的关系。方法选择接受血管造影的236例病人为研究对象,根据造影结果分为病变组与非病变组,比较两组病人的NLR、PLR。根据病人的颈动脉硬化狭窄程度,分析NLR、PLR与狭窄程度的关系,并绘制ROC曲线。结果和无颈动脉狭窄患者相比较,颈动脉狭窄患者PLR、NLR增加(P<0.05),差异有统计学意义;NLR、PLR与病人颈动脉狭窄程度呈正相关(P<0.05),差异有统计学意义。对重度及闭塞的颈动脉狭窄者的PLR、NLR进行ROC曲线分析及计算曲线下面积(AUC),PLR、NLR均有预测价值(P<0.05),PLR的AUC为0.613,最佳截取值为128.41,灵敏性为63%,特异性为58.7%、NLR的AUC为0.616,最佳截取值为2.76,灵敏性为52.1%,特异性为74.6%。结论NLR,PLR对于预判颈动脉的狭窄程度有一定价值。Objective To investigate the relationship between the neutrophil to lymphocyte ratio(NLR),the platelet to lymphocyte ratio(PLR)and the degree of carotid stenosis.Methods The 236 patients who received angiography were selected as study objects.According to the angiography results,the patients were divided into the pathological group and the non-pathological group, and the NLR and PLR of the two groups were compared. The relationship between NLR and PLR and the degree of carotid artery stenosis was analyzed according to the degree of carotid artery stenosis of the patients, and ROC curve was plotted. Results Compared with patients without carotid artery stenosis, PLR and NLR increased in patients with carotid artery stenosis (P<0.05), with statistically significant differences. NLR and PLR were positively correlated with the degree of carotid artery stenosis in the patients(P<0.05), indicating a statistically significant difference. With severe and occlusion of carotid stenosis of PLR and NLR ROC curve analysis and calculate the area under the curve (motorcycle under the curve, AUC). PLR and NLR have predictive value (P<0.05), the AUC of PLR is 0.613, the best capture a value of 128.41, sensitivity of 63%, specificity of 58.7%, the AUC of NLR is 0.616, the best capture a value of 2.76, sensitivity of 52.1%, specificity of 74.6%. Conclusion NLR and PLR are valuable in predicting the degree of carotid stenosis.

关 键 词：颈动脉狭窄 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 

分 类 号：R654.4[医药卫生—外科学]