精子DNA甲基化异常与精液质量相关性的研究进展  

Research progress on the correlation between abnormal sperm DNA methylation and semen quality

作　　者：陈炜康 于冬冬 刘宇鹏 武志刚[1] Chen Weikang;Yu Dongdong;Liu Yupeng;Wu Zhigang(Department of Urology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325035,China;School of Public Administration and Health,Wenzhou Medical University,Wenzhou,Zhejiang 325035,China)

机构地区：[1]温州医科大学附属第一医院泌尿男科,325035 [2]温州医科大学公共管理与卫生学院,325035

出　　处：《中华医学遗传学杂志》2021年第2期188-193,共6页Chinese Journal of Medical Genetics

摘　　要：DNA甲基化是表观遗传学内容之一,在精子发生和胚胎发育中有重要作用。近年来,国内外众多研究发现男性不育症(尤其是精液质量异常)与DNA甲基化异常有关。本文重点阐述了印记基因、一些重复元件和非印记基因异常甲基化与精液质量(包括精子数目、形态和活力)的相关性,旨在进一步研究男性不育的具体机制,为将来临床治疗男性不育症提供新的思路和方法。DNA methylation as an important aspect of epigenetics plays an important role in spermatogenesis and embryo development.In recent years,many studies have found that male infertility,in particular abnormal semen quality,is related to abnormal DNA methylation.To further delineate the pathogenesis of male infertility and provide new ideas for the treatment of male infertility,a comprehensive review over the correlation between abnormal methylation of imprinted genes,repetitive DNA elements and non-imprinted genes,semen quality(including sperm count,morphology,and vitality)and male infertility is provided.

关 键 词：精液质量 DNA甲基化 男性不育症 表观遗传学 

分 类 号：R698.2[医药卫生—泌尿科学]