普通型新型冠状病毒肺炎165例患者的临床和代谢特征  

Clinical and metabolic characteristics in 165 patients with common COVID-19

作　　者：马宇航[1] 周小建[2] 章志健 陈蕊华 孙海燕[1] 林毅[1] 刘军[3] 彭永德[1] 冯晓云[1] Ma Yuhang;Zhou Xiaojian;Zhang Zhijian;Chen Ruihua;Sun Haiyan;Lin Yi;Liu Jun;Peng Yongde;Feng Xiaoyun(Department of Endocrinology and Metabolism,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,China;Department of Pediatrics,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,China;Department of Nephrology,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,China)

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢科,200080 [2]上海交通大学附属第一人民医院儿科,200080 [3]上海交通大学附属第一人民医院肾内科,200080

出　　处：《中华内分泌代谢杂志》2021年第1期23-27,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市自然科学基金(202R1444400)。

摘　　要：目的回顾性分析普通型新型冠状病毒肺炎(COVID-19)康复患者的临床特征和血清学特点。方法收集2020年2月23日至3月15日在湖北省武汉市雷神山医院康复出院的165例普通型COVID-19患者临床资料,按年龄分为老年和非老年组,比较2组患者的临床和血清学代谢特征。结果165例患者中60岁以上老年占49.7%。最常见症状为发热、咳嗽、乏力,其次是肌肉酸痛,咳痰和消化道症状少见。呼吸困难在老年组发生较非老年组更多(47.56%对25.30%,P<0.01)。合并基础疾病以高血压多见,占总人数29.1%,且在老年组表现更为突出(41.46%对16.86%,P<0.01),其次为糖尿病,但2组差异无统计学意义。2组患者血常规白细胞和淋巴细胞计数均在正常范围,且无差异;血清生化检测结果比较显示,血清肌酐老年组患者高于非老年组,血清白蛋白、肾小球滤过率、血清钙在老年组更低,经血清白蛋白校正后血清校正钙均在正常范围,且2组差异无统计学意义。以住院天数作为病情考量指标,2组无明显差异[(34.01±10.24)对(30.97±10.51)d,P>0.05]。结论发热、咳嗽和乏力为普通型COVID-19的最常见症状,老年人发生呼吸困难可能性高。普通型COVID-19患者可表现为正常血常规,也未见特征性代谢异常,但老年COVID-19患者更容易出现血清白蛋白下降。Objective To retrospectively analyze the clinical and serological characteristics in rehabilitated patients with common novel coronavirus pneumonia(COVID-19).Methods A total of 165 patients with common COVID-19 were enrolled in this retrospective study,in which clinical data was collected from February 23 to March 15,2020 in Leishenshan Hospital(Wuhan,China).The patients with COVID-19 were divided into elderly group and non-elderly group according to their age,and the differences in the clinical and serological metabolic characteristics between these two groups were analyzed.Results 49.7%patients were over 60 years old.The most common clinical symptoms were fever,cough,and fatigue,followed by muscle soreness.Expectoration and digestive tract symptoms were rare.Dyspnea occurred more frequently in the elderly group than in non-elderly group(47.56%vs 25.30%,P<0.01).Hypertension was the most common concomitant disease(accounting for 29.1%)followed by diabetes.Hypertension was more common in the elderly group than in non-elderly group(41.46%vs 16.86%,P<0.01),but without significant difference in diabetes between the two groups.The counts of leukocytes and lymphocytes in all patients were in the normal range,and no difference was observed between the groups.The comparison of serological indicators showed that serum creatinine in the elderly group was higher than that in the non-elderly group(P<0.01)while serum albumin,glomerular filtration rate,and serum calcium were lower in the elderly group.After serum albumin correction,the levels of albumin corrected calcium in all patients were in the normal range,without significant difference between these two groups.There was no significant difference between the two groups when the length of hospital stay was taken as the index of outcome[(34.01±10.24)vs(30.97±10.51)d,P>0.05].Conclusion Fever,cough,and fatigue are the most common clinical symptoms in patients with ordinary COVID-19.The elderly are more likely to develop dyspnea.The blood routine and metabolic characteristic

关 键 词：新型冠状病毒肺炎 普通型 老年 临床特征 

分 类 号：R563.1[医药卫生—呼吸系统]