气虚血瘀型急性心肌梗死患者PCI术后应用益气通梗汤对其心肌酶谱及MACE发生率的影响  

Effects of Yiqi Tonggeng Decoction on Myocardial Enzymes and Incidence of MACE in Patients with Acute Myocardial Infarction of Qi Deficiency and Blood-stasis Syndrome after PCI

作　　者：梁重俊 梁瑾[2] LIANG Chongjun;LIANG Jin(Yiyang County Hospital of Traditional Chinese Medicine,Internal Chinese Medicine Hall,He’nan Province 471000)

机构地区：[1]河南省宜阳县中医院中医内科国医堂,471000 [2]河南科技大学第一附属医院检验科

出　　处：《医学理论与实践》2021年第3期361-363,共3页The Journal of Medical Theory and Practice

摘　　要：目的:分析气虚血瘀型急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后应用益气通梗汤对其心肌酶谱及主要不良心血管事件(MACE)发生率的影响。方法:将2016年1月—2018年9月在本院接受PCI手术治疗的131例AMI患者按入院顺序编号,随机数字表法分观察组(n=62)与对照组(n=69)。对照组PCI术后常规给予抗血小板药物等治疗,观察组在对照组基础上给予益气通梗汤,比较两组中医证候积分、心肌酶谱、心功能指标及MACE发生率。结果:治疗后两组中医证候积分、心肌酶谱指标[血清肌钙蛋白(cTnI)、磷酸激酶同工酶(CK-MB)]、左室舒张末内径(LVEDD)较治疗前下降,且观察组低于对照组,左心射血分值(LVEF)较治疗前上升,且观察组高于对照组,差异有统计学意义(P<0.05);两组累积MACE发生率差异无统计学意义(P>0.05),但观察组MACE风险低于对照组,差异有统计学意义(P<0.05)。结论:对气虚血瘀型AMI患者,PCI术后应用益气通梗汤可有效改善症状及心肌损伤,更利于心功能改善,并具更低的MACE风险,值得临床重视。Objective:To analyze effects of Yiqi Tonggeng Decoction on myocardial enzymes and incidence of major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI)of Qi deficiency and blood-stasis syndrome after percutaneous coronary intervention(PCI).Methods:A total of 131 patients with AMI who had undergone PCI in the hospital during the period from January 2016 to September 2018 were divided into observation group(n=62)and control group(n=69)by random number table method.After PCI,control group was treated with routine antiplatelet drugs,and observation group was treated with Yiqi Tonggeng Decoction based on the treatment of control group.TCM symptom scores,myocardial enzymes,cardiac function indexes and incidence of MACE were compared between the two groups.Results:After treatment,TCM symptom scores,myocardial enzymes[serum troponin(cTnI),creatine kinase isoenzyme(CK-MB)]and left ventricular end diastolic diameter(LVEDD)in both groups were decreased,which were lower in observation group than in control group.The left ventricular ejection fraction(LVEF)was increased,and LVEF of observation group was higher than that of control group(P<0.05).There was no significant difference in the cumulative incidence of MACE between the two groups(P>0.05).Risk of MACE was lower in observation group than in control group(P<0.05).Conclusion:For patients with AMI of Qi deficiency and blood-stasis syndrome,application of Yiqi Tonggeng Decoction after PCI can effectively relieve symptoms and myocardial injury,which is conducive to improvement of cardiac function,with a lower risk of MACE.

关 键 词：气虚血瘀型 急性心肌梗死 经皮冠状动脉介入术 益气通梗汤 心肌酶谱 不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]